The Neurobiology of Pain
(Molecular and Cellular Neurobiology)
Series: Molecular and Cellular Neurobiology Series;
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Product details:
- Publisher OUP Oxford
- Date of Publication 22 September 2005
- ISBN 9780198515616
- Binding Hardback
- No. of pages416 pages
- Size 247x174x28 mm
- Weight 851 g
- Language English
- Illustrations 4pp colour plates,numerous halftones, tables and line drawings 0
Categories
Short description:
Within the last decade we have seen major new advances in the neurobiology of pain. The topic has emerged as a separate field of study in its own right. A new volume in the Molecular and Cellular Neurobiology series, this volume presents a state-of-the-art account ot the neurobiological basis of pain, edited and written by leading scientists in this field.
MoreLong description:
The last decade has seen major advances in the neurobiology of pain, primarily resulting from a deeper understanding of the way in which pain signals are coded and processed in the nervous system. This volume in the Molecular and Cellular Neurobiology series is the first book for many years to present an integrated overview of the current state of research into the neurobiology of chronic and acute pain.
While recent molecular aspects of nociception are covered in some detail, the book also emphasises the importance of viewing the pain experience as the co-ordinated response of many different areas of the nervous system. The molecular advances are set in the context of the neurobiological system of pain processing. The appropriate behavioural response to injury can therefore be thought of as the result of the integration of information processed within areas of the brain concerned with cognition, affect, sensory discrimination and movement.
Chapters cover recent advances in nociceptor transduction mechanisms, nociceptor plasticity and the biochemical anatomy of pain pathways. Other contributions are concerned with the development of pain systems and with the central processing of nociceptive information studied with brain imaging techniques. Several chapters additionally cover the mechanisms of clinically important pain states such as neuropathic pain, cancer related pain and migraine.
This volume presents a state-of-the-art account of the neurobiological basis of pain, edited and written by the leading scientists in this field.
...a very well-written book [that] provids a wealth of very interesting and useful information on a rapidly evolving and clinically relevant field, in which there is still a huge unmet need for effective analgesics.
Table of Contents:
Molecular biology of nociceptors
Nociceptor plasticity
Molecular architecture of the dorsal horn
Cellular and molecular mechanisms of central sensitization
Mechanisms of peripheral neuropathic pain
Targets in pain and analgesia
The ascending pain pathways
Spinal delivery of drugs in pain control
The development of pain systems
Visceral and deep somatic pain
The organization of the midbrain periaqueductal grey matter and the integration of pain behaviours
Descending control of pain processing
Central imaging of pain
Headache
An integrative approach to the control of cancer pain
