The Insulin-like Growth Factors
Structures and Biological Functions
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46 819 Ft
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Product details:
- Publisher OUP Oxford
- Date of Publication 16 April 1992
- ISBN 9780198542704
- Binding Hardback
- No. of pages296 pages
- Size 234x156 mm
- Weight 610 g
- Language English
- Illustrations halftones, line illustrations, tables 0
Categories
Short description:
The insulin-like growth factors are peptides which mediate signals for division and differentiation between populations of cells. Recent exciting advances in the study of IGFs have led to insight into their role in embryogenesis, cancer and normal growth. This book reviews what is known of the structure and function of the IGFs. It covers all aspects of the subject, from the organization of IGF genes, to the clinical implications.
MoreLong description:
The past decade has seen an explosion in our understanding of the factors regulating cell proliferation and differentiation. One of the most exciting advances has been the recognition of the pivotal role of the peptide growth factors in these processes.
The insulin-like growth factors, discovered in 1958 by Salmon and Ddaughaday, are now among the best characterized growth factors. Recent advances in knowledge of their receptors and binding proteins together with their purification and cloning have provided exciting insights into the role of these factors in the physiology of normal growth, embryonic development and areas of pathology such as wound healing and cancer.
In this book an international group of contributers review the most up-to-date information on all aspects of the insulin like growth factors, and critically discuss models for IGF action in their own systems. The book will act as a source of information and ideas for researchers, and as an accessible introduction to the subject for students and clinicians.
'An essential text for researchers in this field.'
Aslib Book Guide, Vol. 57, No. 10, October 1992
Table of Contents:
P.N. Schofield: Introduction; W.H. Daughaday: The historical evolution of concepts of the role of insulin-like growth factors; J.L. Van den Brande: Structure of the human insulin-like growth factors: relationship to function; A. Ward & C.J. Ellis: The insulin-like growth factor genes; C. Moxham & S. Jacobs: Insulin-like growth factor receptors; R.H. McCusker & D.R. Clemmons: The insulin-like growth factor binding proteins: structure and biological
functions; P. Bang & K. Hall: Insulin-like growth factors as endocrine and paracrine hormones; V.K.M. Han & D.J. Hill: The involvement of insulin-like growth factors in embryonic and fetal development; E. Jennische, J. Isagaard & O.G.P. Isaksson: Local expression of insulin-like growth factors; P.N. Schofield & W.
Engstrom: Insulin-like growth factors in human cancer; V.R. Sara: The role of insulin-like growth factors in the nervous system; Index.
