The Biochemistry of Cell Signalling
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Product details:
- Publisher OUP Oxford
- Date of Publication 19 July 2001
- ISBN 9780198508205
- Binding Paperback
- No. of pages352 pages
- Size 240x169x20 mm
- Weight 637 g
- Language English
- Illustrations 16pp colour plates, numerous line figures 0
Categories
Short description:
The Biochemistry of Cell Signalling is a comprehensive yet concise study of the principles of cell signalling, concentrating on the structural and mechanistic aspects.
MoreLong description:
The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor
activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein
coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ß in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response. As phosphorylation - dephosphorylation is involved in nearly all cellular regulatory processes, Part 1 concludes with a synopsis of its role in signalling. Part 2 describes the implementation of the signalling cascades focusing on the effect on gene transcription. After a brief
description of the transcriptional machinery the regulation of transcription by cytokines and growth factors in the control of cell growth and the mechanisms and sites of control are discussed in detail. The regulators discussed include Jun/Fos, NF-AT, SREBPs, and STATs. The next two chapters cover gene
regulation by nuclear receptors, including both the steroid hormone receptors and non-steroid nuclear receptors e.g. the retinoic acid receptors RAR and RXR. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. The first chapter concerns the regulation of the cell cycle and the role of the cyclin-dependent kinases, telomerase, Ran, and cell cycle checkpoints. The next topic is the signalling pathways in apoptosis: the TNF-receptor family death
receptors, caspases, and the intracellular apoptosis signals and the role of apoptosis in the lifecycle of cells. Part 3 ends with a discussion of the signal pathways involved in the immune response, focusing on the involvement of cell-cell interactions. Part 4 considers loss of regulatory control
and its consequences with respect to the molecular basis of cancer. It first describes the cellular regulatory proteins that have oncogenic potential, how they can become oncogenic and cause the transformation of normal cells to cancerous cells. Next is an analysis of the loss of developmental controls, the APC protein, ß-catenin, and the Wnt pathway, that lead to mature terminally differentiated cells reverting to immature embryonic cells. The book ends with a summary of the molecular and
cellular causes of cancer and an outlook for novel therapies. Throughout the text, the emphasis is on structure and mechanism and is well illustrated with 200 figures. The Biochemistry of Cell Signalling will be an invaluable companion to all graduate students studying cell signalling.
There is an excellent style and graphic work thoughout the textbook supported by a glossary and an index. Graduate students, post docs and all researchers, who want to understand how cellular activities are organized and regulated, will highly welcome this book.
Table of Contents:
Abbreviations
Part 1: The Machinery of Signal Transduction
Molecular basis of signal transduction
Activation of receptors by oligomerization
Components of signalling networks: linkers and regulators
Signal transduction pathways through small monomeric G proteins
Signal transduction pathways through heterotrimeric G proteins: transmission of hormonal and sensory signals
Signal transduction pathways controlling morphogensis and haematopoiesis
Control of signalling by phosphorylation and dephosphorylation
Regulation by a hormone: the insulin response
Part 2: Cell Signalling and Gene Transcription
Machinery of gene transcription
Regulation of gene transcription by growth factors and cytokines
Regulation of gene transcription by hormones
Part 3: Global Cell Regulatory Programmes
Regulation of the cell cycle
Regulation of cell death
Regulation of the immune response
Part 4: Loss of the Regulatory Control and its Consequences
Transformation of normal cells to tumour cells
Loss of developmental controls in cancer
The causes of cancer
Glossary
Index
