Systems Biology: Volume II: Networks, Models, and Applications
Series: Series in Systems Biology;
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Product details:
- Edition number and title :Volume II: Networks, Models, and Applications
- Publisher OUP USA
- Date of Publication 26 October 2006
- ISBN 9780195300802
- Binding Hardback
- No. of pages366 pages
- Size 160x239x20 mm
- Weight 638 g
- Language English
- Illustrations 74 halftones & line illus. 0
Categories
Short description:
Offers a study of genomic principles and their associated networks and models. Reflecting the hierarchical nature of systems biology, this volume provides discussions on a range of topics, from mass spectrometry to embryonic stem cells. It is useful for both students and researchers.
MoreLong description:
The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes.
Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.
Table of Contents:
Mass Spectrometry in Systems Biology 3
Mathematical Modeling and Optimization Methods for De Novo Protein Design 42
Molecular Simulation and Systems Biology 67
Global Gene Expression Assays: Quantitative Noise Analysis 103
Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 137
Integrating Innate Immunity into a Global "Systems" Context: The Complement Paradigm Shift 169
Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 193
Genome-Scale Models of Metabolic and Regulatory Networks 232
Biophysical Models of the Cardiovascular System 265
Embryonic Stem Cells as a Module for Systems Biology 297
Index 319
