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Product details:
- Edition number 2
- Publisher OUP USA
- Date of Publication 30 May 2002
- ISBN 9780195132618
- Binding Paperback
- No. of pages400 pages
- Size 234x164x18 mm
- Weight 567 g
- Language English
- Illustrations numerous tables and figures 0
Categories
Short description:
The first edition of this book sold about 2,500 copies in total, between Freeman, the original publisher, and Oxford. The field has become increasingly central to the strategies of pharmaceutical companies for drug design, and as a basic research tool for analyzing molecualr recognition and binding. This book provides the most generally useful and balanced treatment of a now-major but still cutting-edge field, with many practical suggestions and problem-solving hints for workers at the bench.
MoreLong description:
The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are oftenunfamiliar with not only the synthetic chemistry but also with important and useful aspects of design, analysis, handling and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well as the latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Its contents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.
MoreTable of Contents:
1. Overview
Synthetic Peptides: Beginning the Twenty-first Century; References
2. Peptide Design Considerations
Protein and Amino Acid Chemistry; Protein Structure; Application of Sequence Analysis to Modeling and Design; Design and Use of Combinational Peptide Libraries; Other Aspects of Peptide Design; Summary; References
3. Principles and Practice of Solid-Phase Peptide Synthesis
Overview of Solid-Phase Strategy; Protection Schemes; Polymeric Support; Attachment to Support; Formation of Peptide Bond; Monitoring Automation of Solid-Phase Synthesis; Cleavage; Post-Translational Modifications and Unnatural Structures; Auxiliary Issues; Summary; Abbreviations; Acknowledgments; References
4. Evaluation of the Synthetic Product
General Considerations; Purification; Detailed Characterization of Covalent Structure; Storage and Handling of Synthetic Peptides; How Much Is Enough; Acknowledgments; References
5. Applications of Synthetic Peptides
Introduction; Structure/Function Studies; Systematic Modifications; Use of Peptides as Enzymatic Inhibitors and Therapeutic Agents; Receptor Studies - A Brief Overview of the Use of Peptides for Studies of Structure-Activity Relationships; The Use of Peptides for Affinity Labeling of Receptors
6. Antigenic and Immunogenic Uses of Synthetic Peptides
Antisense Peptides; Summary and Future Perspectives; List of Abbreviations; Acknowledgements; References; Index
