Sulfonated Derivatives of 2,4-Xylidine: Possible Therapeutic Agents
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Product details:
- Publisher LAP Lambert Academic Publishing
- Date of Publication 1 January 2014
- ISBN 9783659636585
- Binding Paperback
- No. of pages80 pages
- Size 220x150 mm
- Language English 0
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Long description:
Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was synthesized by the reaction of 2,4-dimethylaniline and 4-tosyl chloride (4-methylbenzenesulfonyl chloride) using 10% aqueous Na2CO3 solution as reaction medium. At the second step, the synthesized molecule was made to react with different alkyl/aralkyl halides to yield the target compounds,using N,N-dimethylformamide (DMF) as reaction medium and lithium hydride as an activator. The synthesis of all the compounds was verified by spectral techniques using IR, 1H-NMR and EIMS; and further examined for their anti-enzymatic activities. The synthesized compounds represented the most potential against -glucosidase and lipoxygenase enzymes.
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