Structural Genomics, Part A
Series: Advances in Protein Chemistry and Structural Biology; 75;
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Product details:
- Publisher Elsevier Science
- Date of Publication 18 December 2008
- ISBN 9780123744364
- Binding Hardback
- No. of pages160 pages
- Size 228x152 mm
- Weight 440 g
- Language English 0
Categories
Long description:
Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
MoreTable of Contents:
Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community
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