Preventive Pharmacotherapy of Headache Disorders
Series: Frontiers in Headache Research Series; 12;
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Product details:
- Publisher OUP Oxford
- Date of Publication 26 February 2004
- ISBN 9780198528449
- Binding Hardback
- No. of pages292 pages
- Size 249x174x20 mm
- Weight 600 g
- Language English
- Illustrations numerous figures 0
Categories
Short description:
This book covers the growing body of research aimed at developing medications which can be taken on a regular basis to prevent headcahes from starting.
MoreLong description:
Most of the familiar headache drugs are used to stop a headache attack that is already in progress, or about to begin. However, there is now a growing body of research aimed at developing medications that can be taken on a regular basis to prevent headcahes from starting. These drugs will be targetted at patients whose headaches are frequent or who get their headaches at predicatble times. This book reviews the potential for prophylactic treatment of headache. It provides most of the existing evidence in the field of pharmaco-prophylaxis of migraine and other chronic headaches and may thus, serve as a platform for new initiatives in the field. The book reviews the research into the pharmacological mechanisms involved, the classes of drugs in development and the clinical trials methodology.
The editors have gathered together the leading international experts to produce a book that will appeal neurologists caring for headache patients, researchers in the field and those based in the pharmaceutical industry.
Table of Contents:
Section I - Methodology of prophylactic trials
Principles of preventive pharmacotherapy in primary headache
Methodology and implementation of systematic reviews
Adverse events, equally important as efficacy as an outcome parameter?
Methodology of prophylactic trials: discussion summary
Section II - Prophylactic drugs I
Key issues in the methodology of prophylactic migraine trials
Migraine prophylaxis: a pharmacoepidemiological study of practices used by general practitioners and neurologists in France
Preventive treatment of migraine headache with rofecoxib
Prophylactic treatment and course of the disease in headache associated with sexual activity
Propylactic drugs I: discussion summary
Section III - Prophylactic drugs II
Prevention of migraine: betablockers and amine agonists: efficacy
Antiepileptic drugs in migraine prevention
Mechanism(s) of action of the antiepileptic drugs Valproic Acid, Gabapentin, and Topiramate: implications for the prophylactic management of migraine
Experience with topiramate in patients with refractory migraine
Topiramate in a selective group of therapy refractory headache patients
Prophylactic drugs II: discussion summary
Section IV - Prophylactic Drugs III
Efficacy of antidepressants in headache prophylaxis
Antidepressants: mechanisms of action
Other prophylactic anti-migraine agents: riboflavin feverfew, magnesium, botulinum toxin and calcium antagonists
Treatment of chronic tension type headache with mirtazapine
Botulinum toxin type A in the treatment of refractory headache
Botulinum toxin A in the prophylaxis of migraine - a double-blind, placebo-controlled, randomised study comparing frontal and cervical injection
Description of a prospective, multicenter observational study of headache treatment with Botulinum toxin type A: the program to assess treatment strategies (PATS) registry
Mechanisms of the antinociceptive effect of subcutaneous BOTOX: inhibition of peripheral and central nociceptive processing
Survey on expenditure for analgesics in chronic tension headache and its changes following botulinum toxin type A preventive treatment
Prophylactic treatment of migraine with lomerizine hydrochloride
Prophylactic drugs III: discussion summary
Section V - New Targets I
Antagonising peripheral sensitisation in migraine
New possibilities for antimigraine therapy via 5-HT receptors?
Dihydroergotamine interaction with 5-HT2 receptors and its relevance to migraine
Migraine prophylaxis with drugs influencing the angiotensin system
Naratriptan in the preventive treatment of refractory chronic migraine
PROMISE study (PROphylaxis of MIgraine with SEglor)
Serotinin receptors and migraine prophylaxis - the case of dihydroergotamine
What is the mechanism of action of ACE inhibitors in migraine prophylaxis?
Triptans with methysergide
New Targets I: discussion summary
Section VI - new targets II
Nitric oxide and its signalling pathways: a rich source of potential targets for migraine therapy
Calcitonin gene related peptide and migraine
Phosphodiesterases, cyclic nucleotides, and their role in migraine
The prostaglandin-E1-analog misoprostol in the prophylactic treatment of refractory cluster headache and trigeminal neuralgia
New targets II: discussion summary
