Potential HIV Reverse Transcriptase Inhibitors
Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors
- Publisher's listprice EUR 49.00
-
19 139 Ft (18 228 Ft + 5% VAT)
The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.
19 139 Ft
Availability
printed on demand
Why don't you give exact delivery time?
Delivery time is estimated on our previous experiences. We give estimations only, because we order from outside Hungary, and the delivery time mainly depends on how quickly the publisher supplies the book. Faster or slower deliveries both happen, but we do our best to supply as quickly as possible.
Product details:
- Edition number Aufl.
- Publisher LAP Lambert Academic Publishing
- Date of Publication 1 January 2012
- ISBN 9783659184710
- Binding Paperback
- No. of pages68 pages
- Language English 0
Categories
Long description:
The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.
More
