Polycystic Kidney Disease
Series: Oxford Clinical Nephrology Series;
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108 688 Ft
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Product details:
- Publisher OUP Oxford
- Date of Publication 21 March 1996
- ISBN 9780192625786
- Binding Hardback
- No. of pages606 pages
- Size 248x174x38 mm
- Weight 1293 g
- Language English
- Illustrations halftones, line figures, tables 0
Categories
Short description:
Autosomal dominant polycystic kidney disease is thought to be the commonest disorder inherited autosomally. It is responsible for up to a tenth of all cases of end-stage renal disease and may also cause secondary disorders with a fatal outcome. Understanding of the causes and treatment has advanced rapidly in the last decade, and this book gives a state-of-the-art review of the diseases. It covers a wide range of topics in the natural history, diagnosis, clinical management, underlying genetic investigations, and family counselling of those with polycystic kidney disease, and will be of interest to clinical and research nephrologists worldwide.
MoreLong description:
Many inherited diseases and non-hereditary disorders have in common the development of renal cystic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.
Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis R polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.
a multi-authored, comprehensive review of the hereditary cystic kidney diseases ... There is useful information on virtually every page ... the book is well organized and well referenced, with figures and graphs that clearly augment the written text ... This text makes a useful addition to the clinician's library.
Table of Contents:
Part I: Cystic renal disease: experimental models and pathology
Principles of molecular biology as applied to the study of disease
In vitro models in the study of renal cystogenesis
Mouse models of polycystic kidney disease
In vivo models in non-murine species
Pathogenesis of polycystic kidney disease: basement membrane and extracellular matric
Pathogenesis of polycystic kidney disease: altered cellular function
Part II: Cystic renal disease: clinical spectrum
Classification of cystic kidneys
Diagnostic imaging of renal cystic diseases
Autosomal recessive polycystic kidney disease: clinical and genetic profiles
Acquired renal cystic disease
Tuberous sclerosis
complex
Von Hippel-Lindau Disease
Part III: Adult polycystic kidney disease: natural history and genetics
Definition and natural history of autosomal dominant polycystic kidney disease
Cloning strategies and genetics of type 1 autosomal dominant polycystic kidney diseaseGenetic heterogeneity of autosomal dominant polycystics kidney disease
Part IV: Adult polycystic kidney disease: clinical features
Hypertension in polycystic kidney disease
Progression to renal insufficiency
Management of end-stage renal failure and problems of transplantation in autosomal dominant polycystic kidney disease
Chronic pain and its medical and surgical management in renal cystic disease
Part V: Adult polycystic kidney disease: complications
Miscellaneous renal and systemic complications of autosomal dominant polycystic kidney disease including infection
Polycystic liver disease
Intracranial aneurysms in autosomal dominant polycystic kidney disease
Particular problems in childhood and adolescents in autosomal dominant polycystic kidney disease
Counselling and ethical considerations in autosomal polycystic kidney disease
