Molecular properties prediction and synthesis of oxadiazole analogues
Molecular properties prediction and synthesis of oxadiazole analogues as antimicrobial agents
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Product details:
- Publisher LAP Lambert Academic Publishing
- Date of Publication 1 January 2015
- ISBN 9783659758638
- Binding Paperback
- No. of pages68 pages
- Size 220x150 mm
- Language English 0
Categories
Long description:
A series of 11 oxadiazole analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for antimicrobial screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (4a-k) were evaluated for antibacterial and antifungal activities as per the standard protocol. N-(2-Methylphenyl)-5-(4-chlorophenyl)-1,3,4-oxadiazol-2-amine, 4c was found to have maximum antibacterial activity while N-(2-methylphenyl)-5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-amine, 4d showed maximum antifungal activity.
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