Molecular Nutrition Mechanisms of Cancer Prevention by Schmelz, Eva M.; Neilson, Andrew P.;

Long description:

Molecular Nutrition Mechanisms of Cancer Prevention: A Volume in the Molecular Nutrition Series addresses the relationship between nutrition and cancer at the molecular level. The book covers the epidemiologic evidence of the association between diet and cancer in all forms, including ovarian, breast, prostate and lung. Sections cover physiological factors, such as age, obesity and physical activity, as well as technological factors, such as bioavailability, processing, the molecular mechanisms of cancer prevention by cruciferous vegetables, cocoa, curcumin, garlic extracts, lycopene, resveratrol cancer, olive oil phenols, fiber, soy, calcium, selenium, broccoli sulphuraphane and vitamins which include epigenetic gene regulation.

The regulation of DNA methylation and repair, proliferation of cancer cells, vitamin D receptor polymorphism, vitamins and DNA methylation is also covered, making this book is a welcomed resource for researchers, nutritionists, dieticians, health professionals and students.

• Links physiological concepts and their impact on cancer development
• Provides a summary of the novel and established interactions of diet and cancer
• Highlights the importance of the individual genotype that directs the interaction of diet and cancer
• Discusses controversial topics, such as red meat and cancer risk
• Presents emerging topics relevant for cancer risk, such as microbiota and obesity

Table of Contents:

Part 1: The Intersection of Cancer and Molecular Nutrition 1. Mechanisms of cancer development: an overview 2. Diet and cancer: an overview 3. What large scale studies can tell us about diet and cancer 4. New technologies in cancer prevention research 5. Challenges and ways to move forward -Translational aspects of nutrition research: from cells to mice to man 6. Diet, age and cancer risk 7. Molecular mechanisms of obesity and cancer 8. Dietary fat and cancer risk: an overview 9. Physical activity, energy balance and cancer risk 10. Dietary modulation of chronic inflammation: impact on cancer risk 11. Mediterranean diet and cancer risk 12. Meat consumption, and cancer risk 13. Alternative diets in cancer prevention: risks and benefits 14. Diet and tumor microenvironment 15. Impact of the diet on microbiota 16. Association of microbiome and cancer: Microbiome as target for dietary cancer prevention regimen 17. Bioavailability- impact on preventive potential of bioactive compounds 18. The impact of food processing on bioactive compounds and their functions 19. Interactions of chemotherapy and diet 20. inter-individual differences in the response to diet or dietary compounds

Part 2: Molecular Nutrition Mechanisms of Cancer Prevention 21. Cruciferous vegetables and cancer: Cellular and molecular basis 22. Coffee and tea: chemoprevention of gastric and other cancers 23. Dietary cocoa and colon cancer: cellular and molecular mechanisms 24. Black raspberries in cancer prevention: cellular and molecular mechanisms 25. Curcumin, curcumin-mimics and cancer: Cellular and molecular basis 26. Garlic extracts and cancer prevention: Cellular and molecular basis 27. Lycopene and cancer: Cellular and molecular basis 28. Resveratrol and cancer: Cellular and molecular basis 29. Olive oil phenols and molecular mechanisms of cancer prevention 30. Fiber and molecular biology of cancer (example with butyrate and apoptosis) 31. Soy isoflavones and cancer 32. Epigenetic gene regulation by dietary compounds in cancer prevention 33. Regulation of DNA methylation and repair by B vitamins 34. Vitamin D receptor polymorphism in cancer 35. Calcium and colon cancer: Cellular and molecular mechanisms 36. Selenium, gene regulation and cancer 37. Broccoli sulphuraphane in regulating DNA methylation and HDAC activity 38. Soy isoflavone, genistein, DNA topoisomerase II and cancer: Cellular and molecular basis 39. Polymorphisms in lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1), cancer, diet and serum lipids