Molecular Biology of RNA
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Product details:
- Edition number 2
- Publisher OUP Oxford
- Date of Publication 12 November 2015
- ISBN 9780199671397
- Binding Paperback
- No. of pages440 pages
- Size 266x201x21 mm
- Weight 850 g
- Language English
- Illustrations Over 300 figures; 8 page colour plate section 0
Categories
Short description:
The versatile RNA molecule, along with its many forms and functions, is elegantly captured in this succinct undergraduate text. Molecular Biology of RNA describes how RNA is not only an intrinsic part of the 'central dogma' of molecular biology, but also plays a part in processes as diverse as the regulation of gene expression and catalysis.
MoreLong description:
RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and can even act as a catalyst in the form of a ribozyme. This latter property has led to the hypothesis that RNA - rather than DNA - could have played an essential part in the origin of life itself.
This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. Key pioneering experiments, which provided the underlying evidence for what we now know, are described throughout, while the relevance of the subject to human disease is highlighted via frequent boxes.
For the second edition of Molecular Biology of RNA, more introductory material has been incorporated at the beginning of the text, to aid students studying the subject for the first time. Throughout the text, new material has been included - particularly in relation to RNA binding domains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.
Review from previous edition Highly detailed, and well illustrated, ^Molecular Biology of RNA represents the first text to address exclusively the role of RNA in biological systems.
Table of Contents:
Introduction to Molecular Biology of RNA
RNA can form versatile structures
Catalytic RNAs
The RNA-binding proteins
Pre-mRNA splicing by the spliceosome
Regulated alternative splicing
Pre-mRNA splicing defects in development and disease
Co-transcriptional pre-mRNA processing
Nucleocytoplasmic traffic of messenger RNA
Messenger RNA localization
Translation of messenger RNA
Stability and degradation of mRNA
RNA editing
The biogenesis and nucleocytoplasmic traffic of non-coding RNAs
The 'macro' RNAs: long non-coding RNAs and epigenetics
The short non-coding RNAs and gene silencing
RNA biology: future perspectives
