Molecular Biology of RNA
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Product details:
- Edition number 1
- Publisher OUP Oxford
- Date of Publication 2 December 2010
- ISBN 9780199288373
- Binding Paperback
- No. of pages460 pages
- Size 265x196x22 mm
- Weight 973 g
- Language English
- Illustrations 136 line drawings 0
Categories
Short description:
Molecular Biology of RNA provides a broad survey of RNA structure and function. Describing the life cycle of an RNA, it reveals how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond messenger RNA, including catalysts and regulatory molecules.
MoreLong description:
For many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has become clear; it is far from being merely a staging post between gene and protein. Instead, new insights into RNA structure and function have revolutionized our view of molecular biology, and the role of RNA in
the evolution of life itself.
Molecular Biology of RNA is the first student text to provide a broad survey of RNA structure and function. It leads the reader through the life cycle of an RNA, placing particular emphasis on post-transcriptional events - including post-transcriptional processing and splicing - to reveal how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond that of the messenger RNA, including roles as
catalysts and regulatory molecules.
Throughout the book, descriptions of our current understanding of the field are augmented with examples of pioneer RNA researchers and their key experiments, demonstrating how we have reached our current level of understanding. Further, boxes illustrate the involvement of RNA in the aetiology of human disease, showing how an understanding of the molecular biology of RNA is central to understanding disease processes and their potential treatment.
Molecular Biology of RNA is an essential course text for molecular biology students in the 21st century, capturing the excitement of a field that has changed our understanding of genome function forever.
Online Resource Centre
The Online Resource Centre to accompany Molecular Biology of RNA features:
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Figures from the book in electronic format
This comprehensive textbook is pitched at just the right level and explains the concepts in sufficient detail to make them come to life without swamping the uninitiated with confusing information and jargon. The authors have to be congratulated on the comprehensive nature of the textbook, which means that even RNA aficionados will find useful information within its pages.
Table of Contents:
Introduction to Molecular Biology of RNA
RNA can form versatile structures
Catalytic RNAs
The RNA-binding proteins
Co-transcriptional pre-mRNA processing
Pre-mRNA splicing by the spliceosome
How pre-mRNAs are decoded by the splicing machinery
Regulated RNA processing - alternative splicing
Pre-mRNA splicing defects in development and disease
Nucleocytoplasmic traffic of messenger RNA
Nucleocytoplasmic traffic of non-coding RNA
Messenger RNA localization
Translation of messenger RNA
Stability and degradation of mRNA
RNA editing
The biogenesis of non-coding RNAs
The 'mega RNAs': long non-coding RNAs with important roles in epigenetic regulation of gene expression
The short non-coding RNAs and gene silencing
