Microbiology of Infectious Disease
Integrating Genomics with Natural History
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Product details:
- Publisher OUP Oxford
- Date of Publication 24 March 2022
- ISBN 9780192863850
- Binding Paperback
- No. of pages272 pages
- Size 233x156x12 mm
- Weight 454 g
- Language English 350
Categories
Short description:
This book reverses the trend towards the biology getting lost in molecular detail by cutting through the information overload and placing the new sequence-derived information in the context of the natural history of the organism in question.
MoreLong description:
Prior to the advent of rapid DNA sequencing in the late 90s, students were taught in depth about the physiology and ecology of microorganisms. There was a generally good understanding about the biology of each organism and how it interacted with its environment. Since then, the focus of research has shifted towards an analysis of nucleic acid sequences to determine possible cellular biochemistry or phylogeny. A microbial genome can now be sequenced in a matter of hours, and with the help of a panoply of software programmes the inner workings of the organism can be probed in great detail. However, there is now so much detail that the student or researcher tends to lose any sense of the underlying biology of their study organism. Microbiology has almost become a branch of molecular biology, with the biology getting lost in the molecular detail.
This novel text reverses that trend by cutting through the molecular information overload and placing the new sequence-derived information in the context of the natural history of the organism in question. Each concise chapter has a fascinating and different story to tell, focussing on one pathogen or group of closely related pathogens and highlighting a particularly interesting and/or unusual feature. The aim is to abstract the relevant molecular and genomic information, and then to show how it provides insights into the biology of the organism as a whole.
Microbiology of Infectious Disease is aimed at undergraduates, graduates, and researchers in microbiology, microbial ecology, disease ecology, and related areas. It is intended as a supplemental text for students to provide them with a detailed overview of the biology and natural history of the microorganisms they will routinely encounter and the factors that influence their pathogenicity and infectivity.
Table of Contents:
Preface
Glossary
Part I: An Introduction to the Background Science
The role of nucleic acid analysis in understanding infectious diseases
Some common factors involved in host-pathogen relations
The Three Great Pandemics of Plague
Part II: Bacterial Pathogens
A Multifaceted Pathogen: Escherichia coli
Fever and Food Poisoning: The Two Faces of Salmonella
Understanding Pathogen Populations: Klebsiella pneumoniae
A Surprising Pathogen: Vibrio cholerae
The Accidental Pathogen: Legionella pneumophila
Two Related Pathogens, One Ancient and One New
Helicobacter pylori and Gastric Ulcers
A Tale of Two Pathogens: Pseudomonas aeruginosa and Pseudomonas syringae
The Enigmatic Pathogens: Syphilis, Yaws, Pinta, and Bejel
Mycobacterial Mysteries: Tuberculosis and Leprosy
Plasmids and Pathogenicity: The Bacillus cereus Complex
Tracking the Origins of Clostridium difficile Infections
Tracking Horizontal Gene Transfer: Staphylococcus aureus
The Inadvertent Pathogen: Borrelia burgdorferi and Lyme Disease
Phytoplasmas: Bacteria that Manipulate Plants and Insects
The Most Influential Bacterium: Wolbachia pipientis
Part III: Eukaryotic Pathogens
The Ubiquitous Pathogen: Trichomonas vaginalis
The Greatest Killer of All Times: The Malarial Parasite
An Environmental Opportunistic Pathogen: Cryptococcus
The Most Famous Plant Pathogen: Phytophthora infestans
Part IV
A Virus That Promotes Its Own Transfer: Tomato Spotted Wilt Virus
Morbilliviruses: Measles, Rinderpest and Canine Distemper
Filovirus Haemorrhagic Fevers: Marburg Virus and Ebola
The Origins of HIV and the AIDS Pandemic
The Benefits of a Segmented Genome: Influenza
Third Time Unlucky: SARS, MERS, and Covid-19
Part V: Some Unifying Themes
Zoonotic Diseases
Some Common Pathogenicity Themes
Microbiology of Infectious Disease: Integrating Genomics with Natural History
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