Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis
Series: Annual Reports in Medicinal Chemistry; 52;
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Product details:
- Publisher Elsevier Science
- Date of Publication 7 September 2019
- ISBN 9780128175569
- Binding Hardback
- No. of pages188 pages
- Size 228x152 mm
- Weight 480 g
- Language English 0
Categories
Long description:
Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.
MoreTable of Contents:
1. Tuberculosis
Steven J. Berthel, Christopher B. Cooper and Nader P. Fotouhi
2. Antituberculosis agents: Beyond medicinal chemistry rules
Marco Pieroni
3. Development of MmpL3 inhibitors for tuberculosis treatment
Giovanna Poce, Sara Consalvi, Giulia Venditti, Cristina Scarpecci and Mariangela Biava
4. Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis
Andrew M. Thompson and William A. Denny
5. Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance
Nicolas Willand, Marion Flipo, Baptiste Villemagne, Alain Baulard and Benoit Deprez
6. Sustainable anti-trypanosomatid drugs: An aspirational goal for medicinal chemistry
Maria Laura Bolognesi
