Mechanotransduction and Mechanosensing
Roles and Effects on Biological Systems under Physiological and Pathological Conditions
Series: Results and Problems in Cell Differentiation;
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Product details:
- Publisher Springer Nature Switzerland
- Date of Publication 8 June 2026
- ISBN 9783032195081
- Binding Hardback
- No. of pages455 pages
- Size 235x155 mm
- Language English
- Illustrations VIII, 455 p. 82 illus., 79 illus. in color. 700
Categories
Long description:
This volume explores how cells and tissues sense and respond to mechanical forces, revealing their roles in health and disease, and presenting the latest models and therapeutic strategies in the field of mechanobiology.
All living organisms are subject to mechanical forces, such as tension, compression, shear, torsion, bending and friction. Organisms and their components must sense and respond to these forces. Cells, cellular organelles, tissues and organs detect the physical properties of their internal and external environments, including spatial topography, substrate rigidity, compactness and porosity. After sensing these mechanical cues, they transmit the information to their structural and molecular components. These components then adjust the cell's structure, molecular composition, gene expression, signalling pathways, spatial arrangement, cell cycle, longevity, and other functions.
The book looks at new developments in our understanding of these processes in various cells, describes the roles of mechanosensing and mechanotransduction in disease, and presents novel mechanosensation models and therapeutic approaches.
MoreTable of Contents:
Part I. Mechanoperception Molecules and Organelles, Mechanosensing Models and Mechanics Quantification Tools.- Chapter 1. Mechanosensitive TMEM63 Ion Channels: Structure, Gating Mechanism, and Emerging Physiological and Pathological Roles.- Chapter 2. How Touch Triggers Mechanotransduction in Cutaneous Mechanoreceptors.- Chapter 3. Piezo1 in Immune Cells: From Force to Function.- Chapter 4. Podosomes and Mechanical Force.- Chapter 5. Models of Cellular Mechanosensation.- Chapter 6. StrainMapperJ: An Easy-to-Use Digital Image Correlation Toolkit for Exploring and Quantifying the Mechanics of Deforming Tissues.- Part II. Mechanical Effects on Cellular, Organellar, and Molecular Systems.- Chapter 7. Network-Associated Mechanotransduction in Health and Disease.- Chapter 8. Influence of Magneto-Mechanical Stress on Cellular Membranes, Ion Channel Activity, and Gene Expression Dynamics.- Chapter 9. Setting up to Divide – Nuclear Mechanotransduction in the Regulation of Mitosis.- Chapter 10. Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development.- Chapter 11. Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.- Part III. Tissue- and Organ-Specific Mechanotransduction in Health and Disease.- Chapter 12. Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.- Chapter 13. Integrating Mechanical Loading, Mechanotransduction and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix and Sex.- Chapter 14. Epigenetic Regulation of RUNX2 in Bone Mechanobiology.- Chapter 15. Mechanobiology of Myelin Generation/Regeneration in Health and Disease.- Chapter 16. Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.
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