Hormones and Brain Plasticity
Series: Oxford Series in Behavioral Neuroendocrinology;
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Product details:
- Publisher OUP USA
- Date of Publication 4 June 2009
- Number of Volumes BB
- ISBN 9780195326611
- Binding Hardback
- No. of pages496 pages
- Size 160x236x35 mm
- Weight 850 g
- Language English
- Illustrations 40 illus. 0
Categories
Long description:
The nervous system has a remarkable capacity for self-reorganization, and in this first systematic analysis of the interaction between hormones and brain plasticity, Luis Miguel Garcia-Segura proposes that hormones modulate metaplasticity in the brain. He covers a wide variety of hormones, brain regions, and neuroplastic events, and also provides a new theoretical background with which to interpret the interaction of hormones and brain remodeling throughout the entire life of the organism.
Garcia-Segura argues that hormones are indispensable for adequately adapting the endogenous neuroplastic activity of the brain to the incessant modifications in external and internal environments. Their regulation of neuroplastic events in a given moment predetermines new neuroplastic responses that will occur in the future, adapting brain reorganization to changing physiological and behavioral demands throughout the life of the organism. The cross-regulation of brain plasticity and hormones integrates information originated in multiple endocrine glands and body organs with information coming from the external world in conjunction with the previous history of the organism. Multiple hormonal signals act in concert to regulate the generation of morphological and functional changes in neural cells, as well as the replacement of neurons, glial, and endothelial cells in neural networks. Brain remodeling, in turn, is involved in controlling the activity of the endocrine glands and regulating hormonal secretions. This bidirectional adjustment of brain plasticity in response to hormonal inputs, and adjustment of hormonal concentrations in response to neuroplastic events are crucial for maintaining the stability of the inner milieu and for the generation of adequate behavioral responses in anticipation of--and in adaptation to--new social and environmental circumstances and life events, including pathological conditions.
Hormones and Brain Plasticity is a sophisticated synthesis, integrating theoretical and historical background with state-of-the-art knowledge about just how profoundly, and with exquisite regional and temporal specificity, hormones can impact the entire nervous system throughout the lifespan, in health and disease. Destined to become a fundamental source book in this important field.
Table of Contents:
Hormones and the Mutable Brain
Brain Plasticity Regulates Hormonal Homeodynamics
Hormonal Influences on Brain Plasticity: I. Melatonin, Thyroid Hormones, and Corticosteroids
Hormonal Influences on Brain Plasticity: II. Sex Hormones
Hormonal Influences on Brain Plasticity: III. Peptidergic Hormones
Life Stages, Hormones, and Brain Remodeling: Early Hormonal Influences on Brain Mutability
Life Stages, Hormones, and Brain Remodeling: The Transition from Childhood to Adulthood
Life Stages, Hormones, and Brain Remodeling: Adult Reproductive Life
Life Stages, Hormones, and Brain Remodeling: Disease
Life Stages, Hormones, and Brain Remodeling: Aging
