High-Risk Digestive Tumor Consultations by Carballal Ramil, Sabela; Cubiella Fernández, Joaquín;

Short description:

This manual has been created to provide the necessary knowledge for optimal care in the field of high-risk digestive tumor consultations. It is aimed at a range of healthcare professionals such as gastroenterologists and oncologists, geneticists, and specialists in internal medicine and advanced practice nursing.

Long description:

Digestive tumors are one of the leading causes of cancer mortality, with their prognosis depending significantly on the stage at which they are detected. Therefore, preventive measures are especially important in individuals with genetic alterations, hereditary syndromes, or premalignant lesions, due to their high risk of developing tumors. However, a lack of knowledge and the absence of a multidisciplinary approach and consistency in assessment and follow-up mean that the population considered “high-risk” is not receiving the care it needs.This manual has been created to help solve these shortcomings and provide the necessary knowledge for optimal care in the field of high-risk digestive tumor consultations.

Key features:

• Addresses the molecular and genetic basis of hereditary predisposition to gastrointestinal and pancreatic cancer, develops the psychological and ethical-legal aspects associated with genetic counseling, and describes the skills necessary to carry out this counseling process.


• Examines recognition of the main cancer predisposition syndromes, their prevention, monitoring, and therapeutic management.


• Studies the interpretation of diagnostic tests, especially advanced endoscopic techniques, and the endoscopic and surgical treatment of digestive tumors.


• Prepared by leading experts in the field and taking into account all of the necessary disciplines for managing high-risk digestive tumor consultations.

High-Risk Digestive Tumor Consultations is aimed at any healthcare professional with an interest in digestive oncology (such as gastroenterologists and oncologists), genetic counselling (geneticists), and the doctor-patient relationship (specialists in internal medicine and advanced practice nursing).

Table of Contents:

Part I: Basics of High-Risk Digestive Cancer Consultation  1. Genetic diagnosis in hereditary cancer  2. Ethical and legal aspects of genetic counselling  3. Organization of a high-risk consultation  4. Overview of endoscopy in the prevention of digestive tumors  5. Advanced endoscopy in the detection, characterization, and treatment of digestive tumors  Part II: Hereditary Colorectal Cancer not Associated with Polyposis  6. Hereditary non-polyposis colorectal cancer  7. Lynch syndrome and other causes of DNA repair system disorders  8. Hereditary colorectal cancer beyond Lynch syndrome  Part III: Colorectal Cancer Associated with Polyposis  9. Colorectal polyposis  10. Adenomatous polyposis: definition and variants  11. Adenomatous polyposis: preventive strategies  12. Hamartomatous polyposis  Part IV: Non-Hereditary Forms of High-Risk Colorectal Cancer  13. Non-hereditary familial colorectal cancer 14. Associated colorectal cancer inflammatory bowel disease  15. Serrated polyposis syndrome  16. Non-hereditary adenomatous polyposis and individuals with multiple polyps  17. Post-resection surveillance of adenomatous and serrated polyps  Part V: Familial and Hereditary Gastric Cancer  18. Hereditary gastric cancer: evaluation and diagnosis  19. Diffuse hereditary gastric cancer  20. Other forms of hereditary gastric cancer  21. Familial gastric cancer and prevention strategies in gastric cancer  Part VI: Familial and Hereditary Pancreatic Cancer  22. Associated Syndromes to hereditary pancreatic cancer  23. Hereditary pancreatic cancer: evaluation and diagnosis  24. Familial pancreatic cancer