Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics
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66 563 Ft
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Product details:
- Edition number 2013
- Publisher Springer Berlin Heidelberg
- Date of Publication 9 January 2014
- Number of Volumes 1 pieces, Book
- ISBN 9783642407161
- Binding Hardback
- No. of pages746 pages
- Size 235x155 mm
- Weight 12705 g
- Language English
- Illustrations XXIII, 746 p. 130 illus., 77 illus. in color. Illustrations, black & white 0
Categories
Long description:
Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
MoreTable of Contents:
Brief historical account of HBOC development.- Physiology of respiration.- Oxygen transport to tissues.- Pathophysiology of acute anemia.- Global blood safety and need for safe blood supply.- Blood transfusion and its limitations.- Scientific basis and design of HBOCs.- HBOCs: a regulatory perspective.- Current HBOC products in development.- Clinical indications and clinical trials of HBOCs.- HBOCs and adverse events observed in clinical trials.- HBOC-mediated vasoactivity and hypertension.- HBOC and oxygen and nitrogen radical mediated toxicity.- HBOCs and clinical laboratory interference.- Animal models for HBOC studies.- New emerging Technologies for universal RBCs.- Future prospects.
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