Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues by Tuchin, Valery V.;

Short description:

With an extensive list of references on glucose sensing, glucose monitoring, and light-tissue interaction, this handbook analyzes trends in noninvasive optical glucose sensing and discusses its impact on tissue optical properties. It presents an up-to-date review of commercialized glucose sensors and the underlying science behind their functionality, discusses the fundamentals and basic research of light-tissue interaction, and describes biological fluids that contain glucose on physiological and hyperphysiological levels. The book also details new optical techniques for glucose diffusion coefficient measurements in human tissues and explains glucose-induced optical clearing effects in tissue and blood.

Long description:

Although noninvasive, continuous monitoring of glucose concentration in blood and tissues is one of the most challenging areas in medicine, a wide range of optical techniques has recently been designed to help develop robust noninvasive methods for glucose sensing. For the first time in book form, the Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues analyzes trends in noninvasive optical glucose sensing and discusses its impact on tissue optical properties.

This handbook presents methods that improve the accuracy in glucose prediction based on infrared absorption spectroscopy, recent studies on the influence of acute hyperglycemia on cerebral blood flow, and the correlation between diabetes and the thermo-optical response of human skin. It examines skin glucose monitoring by near-infrared spectroscopy (NIR), fluorescence-based glucose biosensors, and a photonic crystal contact lens sensor. The contributors also explore problems of polarimetric glucose sensing in transparent and turbid tissues as well as offer a high-resolution optical technique for noninvasive, continuous, and accurate blood glucose monitoring and glucose diffusion measurement.

Written by world-renowned experts in biomedical optics and biophotonics, this book gives a complete, state-of-the-art treatise on the design and applications of noninvasive optical methods and instruments for glucose sensing.

Table of Contents:

Preface. Glucose: Physiological Norm and Pathology. Commercial Biosensors for Diabetes. Monte Carlo Simulation of Light Propagation in Human Tissues and Noninvasive Glucose Sensing. Statistical Analysis for Glucose Prediction in Blood Samples by Infrared Spectroscopy. Near-Infrared Reflectance Spectroscopy for Noninvasive Monitoring of Glucose—Established and Novel Strategies for Multivariate Calibration. Characterizing the Influence of Acute Hyperglycaemia on Cerebral Hemodynamics by Optical Imaging. Near-Infrared Thermo-Optical Response of the Localized Reflectance of Diabetic and Non-Diabetic Human Skin. In Vivo Nondestructive Measurement of Blood Glucose by Near-Infrared Diffuse-Reflectance Spectroscopy. Glucose Correlation with Light Scattering Patterns. Challenges and Countermeasures in NIR Noninvasive Blood Glucose Monitoring. Fluorescence-Based Glucose Biosensors. Quantitative Biological Raman Spectroscopy. Tear Fluid Photonic Crystal Contact Lens Noninvasive Glucose Sensors. Pulsed Photoacoustic Techniques and Glucose Determination in Human Blood and Tissue. A Noninvasive Glucose Sensor Based on Polarimetric Measurements through the Aqueous Humor of the Eye. Noninvasive Measurements of Glucose in the Human Body Using Polarimetry and Brewster Reflection off of the Eye Lens. Toward Noninvasive Glucose Sensing Using Polarization Analysis of Multiply Scattered Light. Noninvasive Monitoring of Glucose Concentration with Optical Coherence Tomography. Measurement of Glucose Diffusion Coefficients in Human Tissues. Monitoring of Glucose Diffusion in Epithelial Tissues with Optical Coherence Tomography. Glucose-Induced Optical Clearing Effects in Tissues and Blood. Index.