Short description:

The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology, etiology, and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters, this edition covers the important advances occurring over the past decades.

Long description:

The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology, etiology, and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters, this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity, this topic is studied from biological, behavioural, and environmental perspectives.

Volume 1 is structured into 5 parts:

• Part 1 focuses on the history, definitions, and prevalence of the obesity. It identifies the historical references to excess weight, obesity in art and literature, direct and surrogate measurements of adiposity and obesity related traits, epidemiology of obesity around the globe, and age, sex, and ethnic variation completes this part of the volume


• Part 2 explains the biological determinants of obesity. It explains the bioenergetics, energy dissipation mechanisms and exposure to experimental overfeeding, genetic and epigenetic evidence, metabolic rates, energy expenditure and energy partitioning, and the evidence on infections and adiposity


• Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food, beverages, and ingestive behavior, dealing with smoking, breast-feeding, and sleep duration and pattern, and sedentary behavior, occupational work, and leisure-time physical activity and obesity


• Part 4 comprises of chapters explaining the environmental, social, and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic, social and economic aspects of obesity, and ethnic and cultural differences, and environmental pollutants


• Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease, lipoprotein metabolism, insulin resistance and diabetes, metabolic syndrome, cancer, hepatic biology, pulmonary functions, and arthritis and gout, mental health and quality of life, growth and health disorders in pediatric populations, and on bias and discrimination affecting the obese persons.

Table of Contents:

Preface. About the Editors. Associate Editors. Contributors. Introduction to Volume 1. HISTORY, DEFINITIONS, AND PREVALENCE. From Hippocrates to the Obesity Society: A Brief History. Obesity in Art and Literature. Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat. Anthropometric Indicators of Adiposity in Relation to the Gold Standards. Worldwide and Regional Prevalence of Obesity. Age, Sex, Ethnicity, and Other Sources of Variation in the Prevalence of Obesity. BIOLOGICAL DETERMINANTS OF OBESITY. Bioenergetics and Obesity. Mitochondrial Metabolic Inefficiencies in Skeletal Muscle: Implications for Obesity and Weight Loss. Human Experimental Overfeeding. Biology of Calorie Restriction and Intermittent Fasting. Genetic Epidemiology and Obesity. Genetic Variation and Obesity. Single-Gene Defects and Obesity. Micro and Long RNAs as Regulators in Obesity. Epigenetics and Obesity. T he Role of Adipocyte Precursors in Development and Obesity. Small Animal Models of Obesity. Obesity in Nonhuman Primates. The Transcriptome, Proteome, and Metabolome of Obesity. CNS Regulation of Energy Balance. Gastrointestinal Regulation of Energy Balance. Gut Microbiome and Obesity. Sympathetic Nervous System and Obesity. Hypothalamic?Pituitary Hormones and Obesity. Brown, Beige, and White Adipocyte Development. Adipose Tissue Metabolism, Adipokines, and Obesity. Hepatic, Visceral, Pancreatic, and Cardiac Fat Deposition. Skeletal Muscle Metabolism and Obesity. Resting Metabolic Rate, Thermic Effect of Food, and Obesity. Energy Cost of Exercise, Post-Exercise Metabolic Rates, and Obesity. Energy Partitioning, Substrate Oxidation Rates, and Obesity. COVID-19, Other Microbial Infections, and Obesity. BEHAVIORAL DETERMINANTS OF OBESITY. Obesity and Dietary Intake. Beverages and Obesity: A Review of Current Scientific Evidence. Obesity and Sedentary Time at Work and Home. Leisure Time Physical Activity and Obesity. Role of Early Life Nutrition and Breastfeeding on Obesity Development. Tobacco Use, Marijuana Use, Vaping, and Obesity. Sleep and Obesity. Eating Disorders and Obesity. ENVIRONMENTAL, SOCIAL, AND CULTURAL DETERMINANTS OF OBESITY. The Role of the Food Industry in Obesity. Transportation Policies and Obesity. Urban Environment and Obesity. Social and Economic Factors Related to Obesity across the Globe. Influence of Culture on Obesity. Environmental Chemicals and Obesity. CONSEQUENCES OF OBESITY. Obesity and Mortality. Obesity and Heart Disease. Obesity and Hypertension. Obesity and Lipoprotein Metabolism. Obesity and Insulin Resistance. Obesity and Type 2. Diabetes. Obesity and Metabolic Syndrome. Obesity and Cancer. Obesity and Inflammation. Obesity, Gallbladder, and Gastrointestinal Diseases. Obesity and Liver Diseases. Obesity, Lung Function, and Lung Disease. Obesity and Gout. Obesity, Osteoarthritis, and Bone Disorders. Obesity and Cognitive Decline. Obesity, Mental Health, and Health-Related Quality of Life. Obesity and Reproductive Dysfunction. Obesity in Pregnancy Complications and Outcomes. Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics. Bias, Discrimination, and Obesity. Index.