Genetics of Cellular, Individual, Family, and Population Variability
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Product details:
- Publisher OUP USA
- Date of Publication 2 September 1993
- ISBN 9780195066258
- Binding Hardback
- No. of pages320 pages
- Size 241x162x24 mm
- Weight 718 g
- Language English
- Illustrations halftones, line figures, tables 0
Categories
Long description:
The objective of this book is to review the impact of genetic variation on risk of human disease at the different major levels of organization: cells, individuals, families, and populations. The volume begins with a discussion of sources and rates of mutation which ultimately give rise to the vast amount of extant genetic variation. This is followed by presentations of current understanding of how genetic variation is maintained within and among populations. The volume ends with discussions of the implications of such variation for understanding the evolution of our species. This collection gives an unusually broad treatment of the subject, with chapters from some of the leading workers in the field. James Neel's chapter on human consanguinity effects and M. Otake's on the genetic effects of radiation associated with the dropping of the Hiroshima and Nagasaki atomic bombs should be singled out for special emphasis. As an up-to-date overview of ongoing research, this work will be of interest to a wide range of workers in the fields of human population genetics, evolution, and epidemiology.
Most geneticists will find both useful and interesting material in this volume because of its great breadth and the quality of the authors.
Table of Contents:
Medieval mappaemundi and the conceptual map of genetics: Changing views of cancer biology and other thoughts
Impact of genetic, somatic, and epigenetic variation on phenotype
Impact of genetic variation in individuals - clonal phenotypes other than cancer
Human consanguinity effects revisited: Why is the measurable impact of inbreeding so small?
Genetic risks from exposure to the atomic bombs: Hiroshima and Nagasaki
Genotype by environment interaction - It's a fact of life
Problems and pitfalls in linkage mapping of human genetic diseases: Illustrations from autosomal dominant retinitis pigmentosa (ADRP)
Applications of pedigree analysis to animal models for complex diseases
Genetics of common diseases that aggregate, but do not segregate, in families
Pathodemes: Heredity, environment, and populations of disease susceptibility
Genetic inferences from epidemiologic investigations
Generalized occupancy problem and its applications in population genetics
The maintenance of genetic variation in bacterial populations
Some theoretical predictions for electrophoretic polymorphisms maintained by balancing selection
Application of our understanding of genetic variation in native North America
Genetic variation and evolution of human populations
Nucleotide diversity in man and evidence for the absence of a severe bottleneck during human evolution
Population genetics and evolution in the genus homo in the last two million years
