Genetics and Analysis of Quantitative Traits
Foundations
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Product details:
- Edition number 2
- Publisher OUP Oxford
- Date of Publication 26 August 2025
- ISBN 9780192898180
- Binding Hardback
- No. of pages1184 pages
- Size 285x223x57 mm
- Weight 3490 g
- Language English 792
Categories
Short description:
This second edition of Genetics and Analysis of Quantitative Traits is a fully rewritten and greatly expanded revision of the first edition, published in 1998, which provided the first, modern, unified treatment of quantitative genetics.
MoreLong description:
Almost every trait in nature shows variation, both within populations and between populations and species. The field of quantitative genetics is the very broad umbrella that attempts to separate environmental from genetic sources of variation. As a result, it has powerful applications in animal and plant breeding, evolution, ecology, medicine, anthropology, behaviour, population genetics, conservation biology, genomics, and statistics.
This second edition of Genetics and Analysis of Quantitative Traits is a fully rewritten and greatly expanded revision of the first edition, published in 1998, which provided the first, modern, unified treatment of quantitative genetics. In the past two decades, there have been massive advancements in the field coupled with explosive growth in new quantitative methods; those developments are covered in this new edition.
The book weaves important biological applications with a full development of the theory and appropriate statistical tools. There are extensive discussions of important linear-algebra tools, linear and mixed models, likelihood and Bayesian estimation, as well as false discovery rates, multiple comparisons, and meta-analysis. More than 100 worked examples (ranging from microbes to humans) illustrate the key concepts using real-world applications.
This extensive reference will be suitable for graduate-level students and professional researchers (both empiricists and theoreticians) in the fields of evolutionary biology, genetics, and genomics. It will also be of particular relevance and use to applied evolutionary biologists working in breed improvement for agriculture, human geneticists, and statisticians.
Table of Contents:
Preface
I. Foundations of Quantitative Genetics
An overview of quantitative genetics
Properties of distributions
Covariance, regression, and correlation
Properties of single loci
Sources of genetic variation for multilocus traits
Sources of environmental variation
Resemblance between relatives
Marker-based estimation of relatedness
Introduction to linear models and matrix algebra
Linear and mixed models
Analysis of line crosses
Inbreeding depression
Heterosis and outbreeding depression
Matters of scale
II. Quantiative trait loci
Polygenes and polygenic mutation
Detecting major genes
Principles of marker-based mapping
Linkage mapping and characterizing QTLS: inbred line crosses
Linkage mapping and characterizing QTLS: outbred populations of relatives
Association mapping
Quantitative genomics and probing the nature of quantitative genetic variation
III. Appendices
Expectations, variances, and covariances of compound variables
Path, network, and causality analysis
Further topics in matrix algebra and linear models
Maximum likelihood estimation and likelihood-ratio tests
Computing the power of statistical tests
Multiple comparisons: bonferroni corrections, false-discovery rates, and meta-analysis
Introduction to bayesian analysis
Markov chain monte carlo and gibbs sampling
Experimental Design
