Gene and Cell Therapy
Therapeutic Mechanisms and Strategies
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Product details:
- Edition number 5
- Publisher CRC Press
- Date of Publication 24 September 2026
- ISBN 9780367771799
- Binding Hardback
- No. of pages496 pages
- Size 280x210 mm
- Weight 453 g
- Language English
- Illustrations 32 Illustrations, black & white; 52 Illustrations, color; 24 Halftones, black & white; 46 Halftones, color; 8 Line drawings, black & white; 6 Line drawings, color; 22 Tables, black & white 700
Categories
Short description:
This book presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. This edition also offers more material on the contributors’ research efforts, current technologies, disease targets, and clinical applications.
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Long description:
The most comprehensive, state-of-the-art book on using gene and cell therapy in clinical medicine, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fifth Edition, presents extensive background and basic information, cutting edge technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. The fifth edition of this bestseller continues to provide the most comprehensive coverage of these fields in one volume. Some chapters have expanded introductions, making the book even more suitable for classroom use. This edition also offers more material on the contributors’ research efforts as well as current technologies, disease targets, and clinical applications.
Divided into three sections, the book covers:
• Delivery systems and therapeutic strategies
• Other therapeutic strategies, including technologies that knock down gene expression
• Gene expression, regulation, and detection
• Gene and cell therapies, disease targets, clinical trials, and regulatory issues
Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to novel technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.
Table of Contents:
About the Editors
List of Contributors
Preface
Section I Gene Therapy
1. Biology and Immunology of Recombinant Adeno-Associated Viral Vectors in Gene Therapy
2. Alphavirus Vectors in Gene Therapy and Neuroscience
3. Gene Electrotransfer
4. Evolution of Polyplexes: Refining Structural Motifs Required for Nucleic Acid Delivery
5. Therapeutic Applications of Morpholino Oligonucleotides
6. Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Nuclease Systems
7. Complex In Vitro Models and Their Application in Gene Editing Technologies
8. Gene Therapy for Vision Disorders
Section II Cell Therapies
9. Therapies with Adipose Tissue-Derived Stem/Stromal Cells
10. Placenta-Derived Stem Cells and Their Therapeutic Applications
11. Cell-Based Therapies from Umbilical Cord Blood
12. Cell Therapies for the Treatment of Hepatic Inborn Metabolic Errors
13. Cell Therapies for Gastrointestinal Diseases
14. Cell Therapies for Genitourinary Disorders
15. Translating Stem Cell-Derived Extracellular Vesicle Therapy for Brain Disorders
Section III Cell and Gene Therapy
16. CARtalysts of Change: CAR T Cells at the Intersection of Engineering and Clinical Practice
17. Prenatal Cell and Gene Therapy for Genetic Disorders
18. Cell and Gene Therapies for Cardiovascular Disease
19. Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies
Index
