From Bench to Market
The Evolution of Chemical Synthesis
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Product details:
- Publisher Oxford University Press
- Date of Publication 19 October 2000
- Number of Volumes laminated boards
- ISBN 9780198503842
- Binding Hardback
- No. of pages282 pages
- Size 253x194x21 mm
- Weight 698 g
- Language English
- Illustrations line figures 0
Categories
Short description:
Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule to its entry in the marketplace as a drug. Using real case histories of drug development from
several therapeutic areas, they discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms.
Long description:
Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule, or 'new chemical entity', to its entry in the marketplace as a drug. They discuss all aspects
related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms. The authors use the real chemical history of the development of drugs from several therapeutic areas as
detailed case studies, each chosen to illustrate a range of issues and methodologies in industrial chemistry. Several chapters cover the development of the various ß-lactam antibiotics; two chapters describe the discovery and synthesis of the anticancer drugs Idarubicin and Paclitaxal; in another chapter, the synthesis of the anti-viral drug Acyclovir and the 'patent war' that resulted are explored. Between them, the authors represent considerable first-hand experience in pharmaceutical
research and development. The technical, practical, and strategic information they have amassed make this essential reading for graduate and undergraduate chemists intending to work in the pharmaceutical industry, as well as for industrial chemists themselves. Lecturers teaching courses in medicinal and
organic chemistry will also find it useful.
" I highly recommend this book to process chemists not only in the pharmaceutical industry but in the fine chemical, agrochemical, and colour chemical industries too ... highly recommened - I will certainly use it as a teaching aid " Chemistry in Industry
Table of Contents:
Preface
Process research and development: The modern approach
Non-classical ß-lactam antibiotics
Imipenem
Sanfetrinems
Ritipenems
Losartan
Nabumetone
Acyclovir
Idarubicin
Paclitaxel
The drug discovery process: Towards a new paradigm
