Evolution in Health and Disease
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Product details:
- Edition number 2
- Publisher OUP Oxford
- Date of Publication 22 November 2007
- ISBN 9780199207466
- Binding Paperback
- No. of pages398 pages
- Size 246x188x19 mm
- Weight 883 g
- Language English
- Illustrations 56 b&w line; 1 halftone illustrations 0
Categories
Short description:
A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.
MoreLong description:
In this fully revised and updated edition, the editors have integrated a completely new set of contributions from the leading researchers in the field to describe the latest research in evolutionary medicine, providing a fresh summary of this rapidly expanding field 10 years after its predecessor was first compiled. It continues to adopt a broad approach to the subject, drawing on medically relevant research from evolutionary genetics, human behavioural ecology, evolutionary microbiology (especially experimental evolution of virulence and resistance), the evolution of aging and degenerative disease, and other aspects of biology or medicine where evolutionary approaches make important contributions.
Evolution in Health and Disease describes how evolutionary thinking gives valuable insights and fresh perspectives into human health and disease, establishing evolutionary biology as an essential complementary science for medicine. Integrating evolutionary thought into medical research and practice helps to explain the origins of many medical conditions, including diabetes, obesity, cardiovascular disease, asthma, allergies, other autoimmune diseases, and aging. It also provides life-saving insights into the evolutionary responses of pathogens to antibiotics, vaccinations, and other human interventions. Why are we vulnerable to disease? Why are our bodies not better designed? Are unpleasant surprises in store as we use more antibiotics and vaccines? Why do we respond to inappropriately to so many modern conditions? How do cancers evolve? Why must we grow old? The book discusses answers to these and many other questions while suggesting new approaches to treatment and research.
This research-level text is suitable for graduate-level students and researchers in the fields of evolutionary (Darwinian) medicine, evolutionary biology, anthropology, developmental biology, and genetics. It will also be of relevance and use to medical researchers and doctors.
This book is a veritable treasure trove...The book is written in an extremely clear, mostly nontechnical style.
Table of Contents:
Preface
Part I. Introduction
Introducing evolutionary thinking for medicine
Part II. The history and variation of human genes
Global spatial patterns of infectious diseases and human evolution
Medically relevant variation in the human genome
Health consequences of ecogenetic variation
Human genetic variation of medical significance
Part III. Natural selection and evolutionary conflicts
Intimate relations: evolutionary conflicts of pregnancy and childhood
How hormones mediate tradeoffs in human health and disease
Functional significance of MHC variation in mate choice, reproductive outcome, and disease risk
Perspectives on human health and disease from evolutionary and behavioral ecology
Part IV. Pathogens: resistance, virulence, variation, and emergence
The ecology and evolution of antibiotic resistant bacteria
Pathogen evolution in a vaccinated world
The evolution and expression of virulence
Evolutionary origins of diversity in human viruses
The population structure of pathogenic bacteria
Whole-genome analysis of pathogen evolution
Emergence of new infectious diseases
Evolution of parasites
Part V. Noninfectious and degenerative disease
Evolutionary biology as a foundation for studying aging and aging-related disease
Evolution, developmental plasticity, and metabolic disease
Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks
Cancer: evolutionary origins of vulnerability
Cancer as a microevolutionary process
The evolutionary context of human aging and degenerative disease
References
Index
