Epigenetics, Nuclear Organization & Gene Function
With implications of epigenetic regulation and genetic architecture for human development and health
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Product details:
- Publisher OUP Oxford
- Date of Publication 15 January 2019
- ISBN 9780198831211
- Binding Paperback
- No. of pages306 pages
- Size 247x190x15 mm
- Weight 634 g
- Language English 30
Categories
Short description:
Provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It further aims to highlight the role of the three-dimensional organization of the genetic material itself and its distribution in a functionally compartmentalized nucleus.
MoreLong description:
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine.
This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
This book provides a high-quality and accessible overview of the field of epigenetics, with content organized in a logical sequence . . . [it is] a highly cohesive, logical, and useful volume in which significant content areas are insightfully drawn from the expansive field of epigenetics. It is apparent that the book is written by an individual with a strong breadth of knowledge accumulated from a distinguished career in the field . . . this book, therefore, will be an excellent resource for both those new to epigenetics and seasoned experts
Table of Contents:
Part I
An introduction to epigenetics and epigenetic regulation
Epigenetic phenomena in fungi, plants and animals
The basic structure of chromatin
The basic mechanism of gene transcription
Part II
Transcription is regulated by epigenetic mechanisms
Chromatin modifications and remodeling
Epigenetic chromatin changes and the transcription cycle
The role of non-coding RNAs
Maintenance of the active and inactive states
DNA methylation and gene expression
Regulation of domains and whole chromosomes
Part III
The interplay between transcription and nuclear structure
Architectural organization of the genome
The nuclear envelope
The nucleolus
Nuclear bodies
Part IV
Inheritance of chromatin structure and functional states
Chromosome replication and genomic stability
DNA repair and genomic stability
Inheritance of chromatin modifications through the cell cycle
Stem cells
Nuclear reprogramming and induced pluripotency
Transgenerational inheritance of epigenetic traits
Part V
Epigenetics, human health and development
Aging, cellular senescence and cancer: The role of genomic instability, cellular homeostasis and telomeres
Aging, cellular senescence and cancer: Epigenetic alterations and nuclear remodeling
Developmental systems and their dysfunction
