Epidemiology and Control of Neural Tube Defects
Series: Monographs in Epidemiology and Biostatistics; 20;
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Product details:
- Publisher OUP Oxford
- Date of Publication 31 December 1992
- ISBN 9780192618849
- Binding Hardback
- No. of pages944 pages
- Size 234x156 mm
- Weight 1394 g
- Language English
- Illustrations line drawings, tables 0
Categories
Short description:
This book describes the biology, occurrence, and methods of control of the commonest congenital malformations of the nervous system: neural tube defects, spina bifida, encephalocoele, and anencephalus. It reviews the epidemiology of these conditions and discusses issues such as ascertainment, seasonal variation, ethical and legal issues.
MoreLong description:
Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in aetiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal.
This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.
`Elwood, Little and Elwood have produced an excellent and comprehensive account of the state of neural tube defect research up to 1991.' The Lancet
Table of Contents:
List of contributors
An historical perspective
Classification, anatomy, and embryology
Ascertainment, registration, and assessment of exposure
Geographical variation
Ethnic origin and migration
Secular trends
Seasonal variation
Clustering in time and space
Distribution
Early fetal loss
Associations with multiple pregnancy
Maternal age and reproductive history
Maternal illness and drug use in pregnancy
Socio-economic status and occupation
Diet
Risks in siblings and other relatives
Genetic models
Antenatal screening and diagnosis
Ethical and legal issues
Conclusions
