Emerging Technologies for Heart Diseases by Nussinovitch, Udi;

Long description:

The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation.

Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas.

Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

Table of Contents:

SECTION 1: Treatment of heart failure - device-based therapies and monitoring modalities
1. Keeping a Finger on the Pulse - A brief history of cardiovascular medicine
2. Artificial mechanical hearts and ventricular assist devices
3. Percutaneous left and right ventricular support devices
4. Cardiac resynchronization therapy
5. Left atrial decompression devices
6. Device-based treatment for diastolic heart failure
7. Ultrafiltration and other treatments of volume overload in congestive heart failure
8. Cardiac physical remodeling and percutaneous solutions for the treatment of advanced Heart Failure

SECTION 2: Treatment of systolic heart failure - cell and gene-based therapies, tissue engineering and biopolymers
9. Cardiac xenotransplantation
10. Marrow-derived stromal cells for cardiac regeneration
11. Heart-derived cells for therapeutic application
12. Human Pluripotent Stem Cells for Cardiac Regeneration
13. Heart Regeneration Using Somatic Cells
14. In-vitro engineered heart tissue grafts
15. Decellularization of whole hearts for cardiac regeneration
16. Gene and protein-based therapies for improving cardiac performance and regeneration
17. Biopolymers in the treatment of heart failure and cardiac remodeling

SECTION 3: Treatment of systolic heart failure - novel pharmacological treatments
18. Novel pharmacotherapies for the treatment of heart failure

SECTION 4: Treatment of valvular disorders
19. Heart Valve Tissue Engineering: Current Preclinical and Clinical approaches
20. Transcatheter aortic valve replacement
21. Transcatheter mitral valve repairs for degenerative and Functional mitral regurgitation
22. Transcatheter mitral valve implantation
23. Transcatheter treatments for tricuspid valve diseases