DNA Topology
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Product details:
- Edition number 2 Rev ed
- Publisher OUP Oxford
- Date of Publication 10 February 2005
- ISBN 9780198506553
- Binding Paperback
- No. of pages216 pages
- Size 234x157x12 mm
- Weight 399 g
- Language English
- Illustrations numerous line drawings and halftones 0
Categories
Short description:
DNA as the genetic material is a topic of intense interest in the 21st century with the familiar and iconic Watson-Crick double helix having a vital importance for its function. However, there are further complexities beyond the double helix, including supercoiling, knotting and catenation, that are less widely appreciated and understood but which are critical to its function. This book explains these topological aspects of DNA structure in a clear and approachable style that will be appreciated by both students and researchers interested in DNA structure and function.
MoreLong description:
DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated. However, it has become clear that there are many deviations from this basic structure that have important biological consequences. Prominent among these are the 'topological' configurations: supercoiling, knotting, and catenation (linking). Unfortunately, a full understanding of these features of DNA structure requires the grasp of concepts that can prove difficult for both students and more advanced researchers. This book aims to explain these ideas simply, but rigorously, to allow a wider appreciation of DNA topology.
DNA Topology starts with a basic account of DNA structure before going on to cover DNA supercoiling, the definitions and physical meanings of linking number, twist, and writhe, and the free energy associated with supercoiling. It then considers the rather more complex description of DNA lying on a curved surface and its application to the nucleosome, followed by the phenomena of DNA knotting and catenation. The final chapters deal with the topoisomerases, the enzymes that control DNA topology, and, most importantly, with the biological significance of the topological aspects of DNA structure. Although some of these concepts are quite complex, they are presented in an accessible way, drawing on interesting and relevant examples.
DNA Topology provides a solid basis for understanding the physical properties of DNA and its topology, and how this molecule actively participates in many cellular processes. This book is certainly aimed at specialists, whom it will not diappoint with its detailed treatment of the core subject matter.
Table of Contents:
DNA structure
DNA supercoiling
DNA on surfaces
Knots and catenanes
DNA topoisomerases
Biological consequences of DNA topology
