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    Conceptual Breakthroughs in Comparative Animal Physiology

    Conceptual Breakthroughs in Comparative Animal Physiology by Hicks, James; Wang, Tobias;

    Series: Conceptual Breakthroughs;

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    Product details:

    • Publisher Elsevier Science
    • Date of Publication 1 October 2026

    • ISBN 9780128173664
    • Binding Paperback
    • No. of pages276 pages
    • Size 229x152 mm
    • Weight 450 g
    • Language English
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    Long description:

    Conceptual Breakthroughs in Comparative Animal Physiology tells a story of innate human curiosity about the natural world, and a deeply creative discipline, shaped by varied environments, unusual organisms, elegant experiments, and the persistent effort to understand how animals work and why they work the way they do-along the way discovering “adaptations and mechanisms of the most surprising character”.

    Written by two leading experts in the field, each chapter reflects on the origins of ideas and the approach of turning natural diversity into experimental design. From deserts to oceans, from the anoxia-tolerant animals to endothermic insects, from deep-diving mammals to the integration of “omics,” each chapter follows the discoveries and people who were compelled to modify their view of “what life can do.” The chapters also highlight the long-term influence of key conceptual breakthroughs, demonstrating how insights from comparative physiology have shaped not only the field itself but also, ecology, evolution, and engineering.

    As scientists strive to understand the complexity of living systems, the book underscores the inherent integrative nature of comparative physiology, revealing a process that strives to connect genes to organisms and organisms to environments, and providing a framework for understanding the diversity of life. This is an essential resource for undergraduates, graduate students and researchers interested in physiology with its comprehensive synopsis on the field’s foundational history and significant advances.

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    Table of Contents:

    "1. 1878: Claude Bernard and “la fixit- du milieu int-rieur
    2. 1910 -1961: From Reflexes to Rhythms: The Discovery of Central Pattern Generators
    3. 1914 -1948: The Concept of Critical Oxygen Tension (PcritO2) and the limits of aerobic metabolism
    4. 1929: Homeostasis and the “Wisdom of the Body”
    5. 1929: The Progress of Physiology: August Krogh at the 1929 Congress
    6. 1930 - 1935 Physiology of the Estivating Lungfish: Ecological and Evolutionary Insights
    7. 1930- 1938: The Foundations of Osmoregulation in Aquatic Vertebrates: Early Discoveries in Teleost Fish and Elasmobranchs
    8. 1931 - 1963: The History of Oxygen Secretion in the Fish Swim Bladder
    9. 1932: From Mouse to Elephant: How Kleiber Transformed Our Understanding of Metabolism
    10. 1933: James Gray and the Foundations of Animal Movement
    11. 1935-1949: Krogh and Ussing: The Early Use of Isotopes in Biology
    12. 1936-1961: Cryoprotectants in Comparative Physiology: Convergent Strategies for Life Below Zero
    13. 1939-1942: The Master Switch of Life
    14. 1940-1963: Pioneers of Desert Physiology: The Early Comparative Studies of Water Economy in Mammals
    15. 1941: Myogenic Endothermy in Insects: The mechanism of flight preparation
    16. 1944 The Desert Laboratory: Discovering Reptile Thermoregulation in the Coachella Valley
    17. 1944 - 1950: Breathing in Bursts: Discontinuous gas exchange in insects
    18. 1947: The Fry Paradigm: A Framework for Animal Activity
    19. 1948: Hibernation: connection between metabolism and body temperature
    20. 1949: Beyond One Spike, One Twitch: The Discovery of Asynchronous Muscle
    21. 1950: Coulson and Hernandez and the Alkaline Tide: Acid-Base Physiology in Postprandial Vertebrates
    22. 1950: Thermal Adaptations in Arctic and Tropical Mammals and Birds
    23. 1954: Oxygen Without Red Blood Cells, Life Without Freezing: The Polar Fish Experiment
    24. 1955-1957: Irving, Scholander and the Arctic Lesson: How Vessels Conserve Heat
    25. 1955-1975: The doubly labeled water technique: measuring field energetics
    26. 1958: Beyond the Kidney: The Salt Glands of Marine Birds and Reptiles
    27. 1963: Homeostasis in the Field: The Water Economy of Birds
    28. 1963: Ignition Point: How Arousal from Hibernation Unveiled a Thermogenic Organ
    29. 1963-1993: The Big Four in Comparative Locomotion, Inverted pendulums, running springs, elastic energy storage and dynamic similarity
    30. 1966-67: The Role of the Hypothalamus in Thermoregulation: Contributions from Comparative Physiology
    31. 1966: Low PaCO?: The Signature Physiology of Water Breathers
    32. 1966: How Regional and Facultative Endothermy Transformed the Study of Ectothermic Physiology
    33. 1966: Cardiac Shunts: Mechanisms and Functional Significance
    34. 1966-1972: Cooling the Brain: Countercurrent Exchange and the Carotid Rete
    35. 1966: From Whalers’ Lines to Time-Depth Recorders: Tracing the Limits of Marine Mammal Diving
    36. 1968-1972: Anaerobic Scope and Anaerobic Capacity in Ectotherms
    37. 1968- 1974: The Mystery of Exercise Hyperpnea and the Role of Intrapulmonary Chemoreceptors
    38. 1966-1968: Life Without Oxygen: Metabolic Depression and the Anoxic Turtle
    39. 1970-1975: Comparative Respiratory Physiology and the G-ttingen Models
    40. 1972: Fish Gills Under Competing Demands: Oxygen Uptake vs. Ionic Balance
    41. 1970-1972: The Cost of Transport: A Unifying Measure for Animal Locomotion
    42. 1972: The Buffalo Curve and The Alpha-stat Hypothesis
    43. 1971-72: Avian Gas Exchange: Countercurrent vs. Crosscurrent Mechanisms in Bird Lungs
    44. 1973: Torkel Weis-Fogh: Discovering the Clap-and-Fling Mechanism
    45. 1973-2002: Biochemical Adaptation: A Serendipitous Collaboration that Shaped a Discipline
    46. 1974-1985: Keeping Membranes Fluid: The Discovery of Homeoviscous Adaptations to Temperature and Pressure
    47. 1975: Behavioral Fever and Survival- the Logic of Fever
    48. 1977-1983: The Worms that Changed our View of Life: Chemoautotrophy at Hydrothermal Vents
    49. 1979: Maximum Metabolic Rate and the Making of Endotherms: The Aerobic Capacity Hypothesis
    50. 1980: Breath-Hold Boundaries: Defining the Aerobic Dive Limit
    51. 1980: “Drunken” Goldfish: ETOH production during anoxia
    52. 1981-1994: The Rediscovery of Safety Factors as a Principle of Form and Function
    53. 1981: Strong Ion Difference: Rethinking Acid-Base Balance Beyond Bicarbonate
    54. 1981: Symmorphosis: Economy of Design in the Oxygen Transport Cascade
    55. 1982: Norbert Heisler: preferential regulation of intracellular pH
    56. 1982: Discovering Adrenergic Control of Red Blood Cells: The Na?/H? Exchange Mechanism
    57. 1985: Turning Down the Heat: Comparative Patterns of Hypoxia-Induced Anapyrexia
    58. 1985: A New Way to See Muscle Work: Josephson’s Work-Loop Insight
    59. 1986: Cold Limits, Oxygen Limits: Channel Arrest as a Unifying Strategy
    60. 1987: Charting a New Course: ""New Directions in Ecological Physiology""
    61. 1987: Solvent Drag and Sugar Flow: The Paracellular Pathway for Glucose
    62. 2000: The Rediscovery of Evolutionary Physiology
    63. 1990: Why Animals Don’t Burn Out: The Hidden Boundaries of Sustained Metabolism
    64. 1985-1994: Beyond Just-So Stories: Phylogenies and the Comparative Method
    65. 1994-1998: The Dynamic Cost of Eating: Specific Dynamic Action and the Rise of the “Dynamic Gut” in Comparative Physiology
    66. 1997-2003: Beyond Plasticity: The Dynamics of Phenotypic Flexibility
    67. 2001: Gene Expression Profiling in Non-model Organisms: The Introduction of ‘omics’ to Comparative Physiology
    68. 2001-2008: Limits to Life and The Ongoing Debate on Oxygen, Temperature, and Tolerance
    69. 2006: From Physiological Ecology to Conservation Physiology: Mechanisms with a Mission
    70. 2010: Beyond Birds: Unidirectional Airflow in the Reptilian Lung"

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