Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates
Series: Methods in Enzymology; 459;
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Product details:
- Publisher Elsevier Science
- Date of Publication 2 June 2009
- ISBN 9780123745910
- Binding Hardback
- No. of pages398 pages
- Size 228x152 mm
- Weight 1160 g
- Language English 0
Categories
Long description:
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.
MoreTable of Contents:
Part 1: Polyketides
Overview of polyketide biosynthesis
A) Type I
Structural studies
i) Iterative
Fungal PKSs/FASs
Polyunsaturated fatty acids (PUFAs)
Enediynes
ii) Modular
Macrolides as a paradigm
Macrolides - skipping and stuttering of modules
Trans-AT class
Polyethers
Polyenes
Polyketides in mycobacteria
Docking of subunits
Novel polyketides by genetic engineering
De novo synthesis of pathway genes
Precursor biosynthesis
B) Type II
In vitro analysis and engineering of novel compounds
Bacterial fatty acid biosynthesis
C) Type III
In vitro / in vivo biochemical studies
Structural studies
Part 2: Terpenoids
Enzymology and structural biology of terpenoid biosynthesis
Part 3: Aminocoumarins
Part 4: Carbohydrates
Aminoglycosides
Deoxysugar biosynthesis
