Clinical Studies in Medical Biochemistry
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Product details:
- Edition number 3
- Publisher OUP USA
- Date of Publication 21 September 2006
- ISBN 9780195176889
- Binding Paperback
- No. of pages392 pages
- Size 182x253x17 mm
- Weight 703 g
- Language English
- Illustrations Numerous halftones, tables and line drawings 0
Categories
Short description:
This text uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 33 cases are carefully selected to cover key concepts and common diseases. Each chapter provides a specific patient report that includes the relevant history, pertinent clinical laboratory data, physical findings, and subsequent diagnosis. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease.
MoreLong description:
This text uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 33 cases are carefully selected to cover key concepts and common diseases. Each chapter provides a specific patient report that includes the relevant history, pertinent clinical laboratory data, physical findings, and subsequent diagnosis. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease.
In this third edition of the book, a new co-editor has aided in the substantially revised and more targeted selection of cases. The whole volume is now clearly focussed on intermediary metabolism and other topics central to biochemistry. There are new chapters on topics such as collagen structure, mitochondrial metabolism, and hyperhomocysteinemia and vascular disease. There is also more coverage of nutrional biochemistry, including new chapters on protein-calorie malnutrition, obesity, vitamin A deficiency, and iron metabolism.
The best cases were retained from the previous edition, and have been completely rewritten and updated to include recent advances in diagnostic biochemistry and the status of current therapies. Although the first edition was intended primarily for medical students, through the years the book has proven useful for a wide variety of students interested in the health science professions.
Table of Contents:
Part I: Nucleic Acids and Protein Structure and Function
Fragile X Syndrome
Sickle Cell Anemia
Osteogenesis Imperfecta
a1-Antitrypsin Deficiency
Cardiac Troponin: Clinical Role in the Diagnosis of Myocardial Infarction
Hereditary Spherocytosis
Part II: Fuel Metabolism and Energetics
Pyruvate Dehydrogenase Complex Deficiency
Mitochondrial Encephalomyopathy, Lactic Acidos, and Stroke-Like Episodes (MELAS): A Case of Mitochondrail Disease
Systemic Carnitine Deficiency: A Treatable Disorder
Neonatal Hypoglycemia and the Importance of Gluconeogenesis
Part III: Intermediary Metabolism
Glucose-6-Phosphate Dehydrogenase Deficiency and Oxidative Hemolysis
Biotinidase Deficiency: A Biotin-Responsive Disorder
Adrenoleukodystrophy
Low-Density Lipoprotein Receptors and Familial Hypercholesterolemia
Tangier Disease: A Disorder in the Reverse Cholesterol Transport Pathway
Gaucher Disease
I-Cell Disease (Mucolipidosis II)
Inborn Errors of Urea Synthesis
Phenylketonuria
HMG-CoA Lyase Deficiency
Hyperhomocysteinemia
Neonatal Hyperbilirubinemia
Part IV: Digestion, Absorption, and Nutritional Biochemistry
Obesity: A Growing Problem
Protein-Energy Malnutrition
Lactose Intolerance
Pancreatic Insufficiency Secondary to Chronic Pancreatitis
Abetalipoproteinemia
Vitamin B12 Deficiency
Vitamin A Deficiency in Children
Calcium-Deficiency Rickets
Hereditary Hemochromatosis
Part V: Endocrinology and Integration of Metabolism
Type I Diabetes Mellitus
Congenital Adrenal Hyperplasia: P450c21 Steroid Hydroxylase Deficiency
