Classical Hematology by Abutalib, Syed A.; Connors, Jean M.; Ragni, Margaret V.;

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Master Classical Hematology with Confidence

This fully revised second edition offers a comprehensive, clinically focused exploration of Classical Hematology through a clear and engaging Q&A format. Designed to support hematologists and oncologists in everyday decision-making, it provides practical, evidence-based answers to both common and complex clinical challenges.

Spanning the full breadth of the specialty, the book features 74 expertly authored chapters organized into ten well-structured sections, covering:

• Red cell disorders
• Hemostasis, bleeding and thrombosis
• Thrombosis and coagulopathy in medical and surgical settings
• Medications affecting thrombosis and bleeding
• White cell abnormalities
• Hematologic disturbances in HIV and SARS-CoV-19 infections
• Fertility, women’s and neonatal health
• Transfusion medicine
• Hematopoietic growth factors
• Blood smear interpretation

A hallmark of this volume is the opportunity it provides physicians to engage with well-reasoned perspectives on challenging hematologic issues. The result is a practical, immediately applicable reference that bridges knowledge and clinical practice.

Accessible, comprehensive, and up to date, this essential Q&A resource is invaluable for residents, fellows, house officers, and experienced practitioners alike—and an outstanding companion for those preparing for internal hematology examinations and board certification.

Table of Contents:

Part 1 Red cell disorders.- 1. Evaluation of Anemia in Children and Adults.- 2. Iron Homeostasis.- 3. Diagnosis and Management of Iron Deficiency Anemia.- 4. Iron Overload: Diagnosis, Complications, and Management.- 5. Anemia of Inflammation.- 6. Megaloblastic and Nutritional Anemias.- 7. Extrinsic Hemolytic Anemias.- 8. Intrinsic Hemolytic Anemias: Non-Hemoglobinopathies.- 9. Sideroblastic Anemias.- 10. Porphyrias: Diagnosis and Management.- 11. Disorders of Hemoglobin Synthesis: Pathophysiology and Diagnostic Evaluation.- 12. Thalassemia: Management Issues.- 13. Sickle Cell Disease: Outpatient Management and Prevention of Complications.- 14. Sickle Cell Disease: Management of Complications.- 15. Paroxysmal Nocturnal Hemoglobinuria and Pure Red Blood Cell Aplasia.- Part 2 Hemostasis and Bleeding Disorders.- 16. Coagulation and Fibrinolysis Pathways.- 17. Diagnostic Tests for Platelet Disorders.- 18. Principles of laboratory tests for vWF and coagulation factor function and disorders.- 19. Von Willebrand Disease: Differential Diagnosis and Diagnostic Approach to Specific Subtypes.- 20. von Willebrand Disease: Management.- 21. Hemophilia A.- 22. Hemophilia B.- 23. Coagulation Factor Inhibitors.- 24. Gene Therapy in Bleeding Disorders.- 25. Hereditary Disorders of Fibrinogen.- 26. Rare Clotting Factor Deficiencies.- 27. Fibrinolysis System: Disturbances and Clinical Implications.- 28. Inherited Platelet Disorders: Diagnosis and Management.- 29. Immune Thrombocytopenia.- 30. Other Acquired Platelet Disorders.- Part 3 Thrombosis.- 31. Hereditary Thrombophilias: Pathophysiology, Interpretation and Indications for Testing.- 32. Antiphospholipid Antibodies and Syndrome.- 33. Heparin-Induced Thrombocytopenia (HIT): Diagnosis and Management.- 34. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.- 35. Unidentifiable Thrombophilia.- 36. Prevention of Venous Thromboembolism.- 37. Venous Thromboembolism: Management.- 38. Complications of Venous Thromboembolic Disease.- 39. Arterial Thromboembolism.- 40. Surgical and interventional treatment of acute venous thromboembolic disease.- Part 4 Coagulopathy in Systemic and Surgical Disorders.- 41. Hemostasis Disturbances in Acute Leukemias and Myelodysplastic Neoplasms.- 42. Bleeding and Thrombosis in a Cancer Patient.- 43. Coagulopathy in critically ill patients.- 44. Trauma-Induced Coagulopathy.- 45. Management of the Surgical Patient with Thrombotic and Bleeding Diathesis.- Part 5 Medications in Thrombosis and Bleeding Disorders.- 46. Antiplatelets.- 47. Anticoagulation Agents and Thrombolytics.- 48. Antifibrinolytics.- Part 6 White Cell Abnormalities.- 49. Duffy-Null Associated Neutrophil Count.- 50. Primary Immunodeficiency Disorders: Diagnosis and Management.- 51. Disorders of Phagocytic Function and Number: Diagnosis and Treatment.- 52. Inherited Bone Marrow Failure Syndromes: Diagnosis and Management.- 53. Immune Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria.- 54. Lysosomal Storage Disorders: Hematology Perspective.- 55. Hemophagocytic Lymphohistiocytosis: Diagnosis and Management Challenges.- 56. Nonmalignant Leukocyte Disorders.- 57. Eosinophilia.- 58. Cryoglobulins and Cryoglobulinemia.- 59. Castleman Disease with and without Viral Infection(s) and Rosai-Dorfman-Destombes Disease.- Part 7: Disturbances in HIV and SARS-CoV-19 Infections.- 60. Hematologic Complications of HIV-Infection.- 61. Antithrombotic Management in SARS-CoV-2 infection.- Part 8: Fertility, Women’s and Neonatal Health Issues.- 62. Hematologic Changes and Special Issues in Pregnancy.- 63. Thrombosis and Bleeding in Pregnancy.- 64. Fertility and Pregnancy in Patients with Thalassemia.- 65. Pregnancy and fertility issues in women with sickle cell disease.- 66. Alloimmune Hemolytic Anemia of the Fetus and Newborn.- 67. Developmental Coagulopathies.- 68. Congenital Erythrocytosis.- Part 9 Transfusion Medicine.- 69. Pre-transfusion testing methods and implications.- 70.Transfusion of Red Blood Cells.- 71. Transfusion of Platelets.- 72. Transfusion of Plasma Products.- Part 10. Hematopoietic Growth Factors and Blood Smears.- 73. Hematopoietic Growth Factors.- 74. Diagnosis from Blood Smear.