Chymotrypsin Inhibitors:N-substituted sulfamoylacetamides
N-substituted sulfamoylacetamides derived from 4-acetamidobenzenesulfonyl chloride as Chymotrypsin Inhibitors
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15 584 Ft (14 842 Ft + 5% VAT)
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15 584 Ft
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Product details:
- Publisher LAP Lambert Academic Publishing
- Date of Publication 1 January 2014
- ISBN 9783659648915
- Binding Paperback
- No. of pages72 pages
- Size 220x150 mm
- Language English 0
Categories
Long description:
A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides (3a-q) by the reaction of 4-acetamidobenzenesulfonyl chloride with a series of different alkyl/aralkyl/aryl amines in aqueous alkaline media under dynamic control of pH at 9-10. The structures of the synthesized N-substituted sulfamoylacetamides were elucidated through spectral analysis like FT-IR, EIMS and 1H-NMR. The synthesized derivatives were further screened against Chymotrypsin enzyme. The results revealed that most of the synthesized compounds were found to be potent chymotrypsin inhibitor.
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