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    Cellular Peptide Hormone Synthesis and Secretory Pathways

    Cellular Peptide Hormone Synthesis and Secretory Pathways by Rehfeld, Jens F.; Bundgaard, Jens R.;

    Series: Results and Problems in Cell Differentiation; 50;

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      • Publisher's listprice EUR 213.99
      • The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.

        90 774 Ft (86 451 Ft + 5% VAT)
      • Discount 20% (cc. 18 155 Ft off)
      • Discounted price 72 619 Ft (69 161 Ft + 5% VAT)

    90 774 Ft

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    Availability

    Estimated delivery time: In stock at the publisher, but not at Prospero's office. Delivery time approx. 3-5 weeks.
    Not in stock at Prospero.

    Why don't you give exact delivery time?

    Delivery time is estimated on our previous experiences. We give estimations only, because we order from outside Hungary, and the delivery time mainly depends on how quickly the publisher supplies the book. Faster or slower deliveries both happen, but we do our best to supply as quickly as possible.

    Product details:

    • Edition number 2010
    • Publisher Springer
    • Date of Publication 4 May 2012
    • Number of Volumes 1 pieces, Previously published in hardcover

    • ISBN 9783642262760
    • Binding Paperback
    • No. of pages239 pages
    • Size 235x155 mm
    • Weight 385 g
    • Language English
    • Illustrations 36 Illustrations, black & white
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    Short description:

    The purpose of the present volume is to illustrate the modern biological concept of basic endocrinology in one single book. It first describes general issues such as maturation of secretory granules in the cells, the roles of the chaperonic granins, and cell-specific prohormone processing. Subsequently, the specific part of the book illustrates the new endocrine biology, using as examples a broad variety of individual peptide systems: ACTH, Neurotensin and Neuromedines, Natriuretic Peptides, Glucagon and Glucagon-like peptides, Somatostatin, Ghrelin, Gastrin and VIP (Vasoactive Intestinal Polypeptide).

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    Long description:

    The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones ? including the old master hormone insulin ? represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.

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    Table of Contents:

    VIP and PACAP.- Biosynthesis of Cardiac Natriuretic Peptides.- Chromogranins A and B and Secretogranin II as Prohormones for Regulatory Peptides from the Diffuse Neuroendocrine System.- Neurotensin and Neuromedin N Are Differentially Processed from a Common Precursor by Prohormone Convertases in Tissues and Cell Lines.- Ghrelin: From Gene to Physiological Function.- Somatostatin and Somatostatin Receptors.- ACTH: Cellular Peptide Hormone Synthesis and Secretory Pathways.- Maturation of Secretory Granules.- Cell-Specific Precursor Processing.- Posttranslational Processing of Progastrin.- Glucagon and Glucagon-Like Peptides 1 and 2. 

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    Cellular Peptide Hormone Synthesis and Secretory Pathways

    Cellular Peptide Hormone Synthesis and Secretory Pathways

    Rehfeld, Jens F.; Bundgaard, Jens R.; (ed.)

    90 774 HUF

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