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  • Cardiovascular Physiology in the Genetically Engineered Mouse

    Cardiovascular Physiology in the Genetically Engineered Mouse by Hoit, Brian D.; Walsh, Richard A.;

    Series: Developments in Cardiovascular Medicine; 238;

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      • Publisher's listprice EUR 160.49
      • The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.

        66 563 Ft (63 393 Ft + 5% VAT)
      • Discount 20% (cc. 13 313 Ft off)
      • Discounted price 53 250 Ft (50 714 Ft + 5% VAT)

    66 563 Ft

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    Estimated delivery time: In stock at the publisher, but not at Prospero's office. Delivery time approx. 3-5 weeks.
    Not in stock at Prospero.

    Why don't you give exact delivery time?

    Delivery time is estimated on our previous experiences. We give estimations only, because we order from outside Hungary, and the delivery time mainly depends on how quickly the publisher supplies the book. Faster or slower deliveries both happen, but we do our best to supply as quickly as possible.

    Product details:

    • Edition number 2
    • Publisher Springer US
    • Date of Publication 31 October 2001
    • Number of Volumes 1 pieces, Book

    • ISBN 9780792375364
    • Binding Hardback
    • See also 9781461356615
    • No. of pages403 pages
    • Size 235x155 mm
    • Weight 1690 g
    • Language English
    • Illustrations XIV, 403 p. Illustrations, black & white
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    Long description:

    The enormous advances in molecular biology and genetics coupled with the progress in instrumentation and surgical techniques have produced a voluminous and often bewildering quantity of data. The need for a second edition of Cardiovascular Physiology in the Genetically Engineered Mouse is underscored not only by these rapid advances, but by the increasing numbers of scientists who have focussed their research on genetically engineered mice. It is the primary objective of this second edition to interpret critically the literature and to provide a framework for the enormous amount of information in this burgeoning field. As in the first edition, the monograph serves as a practical guide for the investigator interested in the functional methods used to characterize the murine cardiovascular phenotype. However, this guidebook is a more comprehensive text than its predecessor; although the major objectives enumerated in the first edition have not substantially changed, they have been refined in keeping with the increased sophistication of the molecular biologist, geneticist, and physiologist in each other's discipline. Each chapter has been expanded and updated, richly enhanced with original tables and figures, and in many cases, extensively rewritten. Eight chapters written by internationally recognized experts have been added; this represents a 43 % increase from the first edition.

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    Table of Contents:

    One.- 1. The Hierarchical Approach to Analysis of Cardiovascular Function in Mice: An Overview.- 2. Genetic Alterations and Modeling of Cardiovascular Physiology.- 3. Conditional Transgenesis.- 4. Array Transcription Profiling: Molecular Phenotyping Of Rodent Cardiovascular Models.- 5. Murine Cardiovascular Development.- Two.- 6. Isolated Myocyte Mechanics and Calcium Transients.- 7. Single Cell Patch-Clamp Analysis of Mouse Cardiac Myocytes.- 8. The Isolated Isovolumic (Langendorff) Heart Preparation.- 9. The Isolated Work-Performing and Ejecting Mouse Heart Preparation, Comparison and Quantification of Cardiac Performance in Transgenic and Wild-type Mice.- 10. 31P NMR Spectroscopy of the Mouse Heart.- 11. Electrophysiological Characterization of the Mouse Heart Using Voltage-Sensitive Dyes.- 12. Echocardiographic Assessment of the Mouse Heart and Aorta.- 13. In Vivo Invasive Hemodynamic Studies in Mice.- 14. Pressure-Volume Relations.- 15. Assessment of Left Ventricular Diastolic Function in Mice.- 16. In Vivo Electrophysiologic Studies in Mice.- 17. Cardiovascular Physiology in Mice: Conscious Function Measurements and Effects of Anesthesia.- 18. Exercise and Oxygen Consumption in the Mouse.- 19. Clinical Laboratory Analysis of the Genetically Manipulated Mouse.- Three.- 20. Smooth Muscle Studies Using Gene-Altered Mouse Models: A Users’ Guide.- 21. Models of Cardiac Disease in the Mouse, Cardiac Hypertrophy and Heart Failure.- 22. Analysis of Murine Embryonic Cardiovascular Phenotype.- 23. Newer In Vivo Imaging Modalities.

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