Basic Principles of Drug Discovery and Development
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Product details:
- Edition number 2
- Publisher Elsevier Science
- Date of Publication 30 June 2021
- ISBN 9780128172148
- Binding Paperback
- No. of pages712 pages
- Size 229x152 mm
- Weight 1130 g
- Language English 125
Categories
Long description:
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics.
Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.
MoreTable of Contents:
1. Drug Discovery and Development: An Overview of Modern Methods and Principles
2. The Drug Discovery Process: From Ancient Times to the Present Day
3. Classical Targets in Drug Discovery
4. In Vitro Screening Systems
5. Medicinal Chemistry
6. In vitro ADME and In vivo Pharmacokinetics
7. Animal Models of Disease States
8. Safety and Toxicology
9. Antibody Drug Discovery
10. Basics of Clinical Trials
11. Translational Medicine and Biomarkers
12. Organizational Considerations and Trends in the Pharmaceutical Industry
13. Intellectual Property and Patents in Drug Discovery
14. Case Studies in Drug Discovery
