ABC Proteins
From Bacteria to Man
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58 199 Ft
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Product details:
- Publisher Academic Press
- Date of Publication 7 January 2003
- ISBN 9780123525512
- Binding Hardback
- No. of pages530 pages
- Size 279x203 mm
- Weight 2005 g
- Language English
- Illustrations Approx. 100 illustrations 0
Categories
Long description:
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.
Key Features
* Phylogeny and Evoloution of ABC Transporters
* Fundamental Aspects of the Mechanism of Action of ABC Transporters
* Prokaryote ABC Transporters
* Non-Mammalian Transporters
* Multidrug Transporters
* ABC Transporters, Physiological Roles and Human Disease
* Full color throughout
"...the volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astonishingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy."
-CELL (July 2003)
"The editors of ABC Proteins: From Bacteria to Man have valiantly attempted to encompass in this volume the entire scope of research on these proteins, from atomic-resolution structure to human genetic diseases, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana...
What the book makes obvious is that nearly all ABC proteins are membrane localized, ATP dependent, primary active transporters...In addition to advances in our understanding of ABC transporter structure, several chapters in the book also describe progress that has been made in elcuidating the mechanisms of transport.
The volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astoundingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy. Finally, this book makes a convincing case that many laboratories that may not yet suspect it will soon have a much more abiding interest in ABC proteins."
"...well organized and included beautifully clear color images and figures."
-E STREAMS (July 2003)
Table of Contents:
Preface.
Introduction.
PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERS
Phylogenetic and Functional Classification of ABC (ATP-binding cassette) Systems
Membrane Topology of the Human ABC Transporter Proteins
Human and Drosophila ABC-Proteins
PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERS
Structure and Modular Organization of ABC-Transporters
Substrate Binding Sites in ABC-Transporters
Probing of Conformational Changes,Catalytic Cycle and ABC-Transporters Function
X-ray Structure of an Intact ABC-Transporter, MsbA
PART 3-PROKARYOTE ABC-TRANSPORTERS
Introduction to Bacterial ABC-Transport Systems
Import of Solutes by ABC-Transporters-The Maltose System
Crystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their Function
Bacterial ABC-Transporters Involved in Protein Translocation
Bacterial Multidrug Resistance Mediated by ABC-Transporters
Structure and Function of Osmoregulated ABC Transporters
PART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERS
Inventory & Evolution of Fungal ABC Protein Genes.
Fungal ABC Proteins in Clinical Drug Resistance & Cellular Detoxification
Drug Resistance Mediated by ABC Transporters in Parasites of Humans
The Plant ABC Transporter Superfamily: the Functions of a Few and Identities of Many
PART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERS
Solving the Problem of Multidrug Resistance: ABC Transporters in Clinical Oncology
Multidrug Resistance Protein 1 (ABCC1)
MRP2, the Apical Export Pump for Anionic Conjugates
The Multidrug Resistance Proteins 3-7
Lipid Transport by ABC Transporters
Role of ABCA1 in Cell Turnover and Lipid Homeostasis
Peroxisome ABC-Transporters
ABC-Transporters in Mitochondria
The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune Responses
The Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel Regulator
ABC-Transporters and Human Eye Disease
Structure Function Analysis of CFTR
