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    Transglutaminase: Fundamentals and Applications

    Transglutaminase by Zhang, Yi; Simpson, Benjamin K.;

    Fundamentals and Applications

    Sorozatcím: Foundations and Frontiers in Enzymology;

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    A termék adatai:

    • Kiadó Academic Press
    • Megjelenés dátuma 2024. február 29.

    • ISBN 9780443191688
    • Kötéstípus Puhakötés
    • Terjedelem382 oldal
    • Méret 234x190 mm
    • Súly 810 g
    • Nyelv angol
    • 591

    Kategóriák

    Hosszú leírás:

    Transglutaminase: Fundamentals and Applications, a new volume in the Foundations and Frontiers in Enzymology series, stands as a comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field, international experts discuss basic biology and structure - function relationships of transglutaminases, ongoing fundamental research, and new application areas, including food processing, material synthesis, biomedicine, disease treatment, and biotechnology. Approaches for sourcing transglutaminases from animals, plants, and microorganisms are considered, followed by chapters on applied uses in biomedicine, skin, bone biology, medicine, drug development, tissue engineering, seafood bioprocessing, dairy bioprocessing, synthesis of materials and polymers, and as an immobilization agent.

    Research protocols are also provided, including research rationale, design, substrates, assays, and microassay steps for studying transglutaminases.

    Több

    Tartalomjegyzék:

    An introduction to transglutaminases
    Yi Zhang, Srividya Parthasarathy, and Benjamin K. Simpson

    Chapter 1 Transglutaminases from microorganisms
    Limin Wang and Yi Wang
    1. Introduction
    2. Microbial sources of TGase
    3. Biotechnological production of MTGase
    4. Concluding remarks and outlook
    References

    Chapter 2 Transglutaminases from plant sources
    Stefano Del Duca and Giampiero Cai
    1. Introduction
    2. Phylogenetic relationship and bioinformatic analyses
    3. Distribution and physiological roles of TGases in plants
    4. Conclusions
    References

    Chapter 3 Transglutaminases from animals
    Jirawat Yongsawatdigul, Ali Hamzeh and Bung-orn Hemung
    1. Introduction
    2. Function and distribution
    3. Conclusions
    References

    Chapter 4 Newly engineered transglutaminases
    Han Liu, Ishita Ghosh, Corinne Nardin and Yi Zhang
    1. Introduction
    2. Methodology for engineering transglutaminases
    3. Newly engineered microbial transglutaminases
    4. Newly engineered animal transglutaminases
    5. Regulations
    References

    Chapter 5 Transglutaminase 2 in neurological conditions
    Thomas Delgado and Gail V.W. Johnson
    1. Discovery of TG2 and its association with proteinopathies
    2. TG2’s complex role in neuron survival
    3. TG2 in CNS injury and neuroinflammation
    4. Epigenetic regulation by TG2
    5. Conclusions
    References

    Chapter 6 Transglutaminases in cardiovascular health and disease
    Lakshmi Santhanam
    Abbreviations
    1. Introduction
    2. Transglutaminases in the cardiovascular system
    3. Transglutaminases in vascular diseases
    4. Transglutaminases in cardiac disease
    5. Transglutaminases in thromboembolism
    6. Conclusions and future perspectives
    References

    Chapter 7 Microbial transglutaminase in drug development
    Riko Nishioka, Ryo Sato, Kazuki Uchida, Rie Wakabayashi and Noriho Kamiya
    1. Introduction
    2. Protein modification using small molecule substrates
    3. Preparation of proteineprotein conjugates
    4. Protein modification using synthetic polymeric substrates
    5. Introduction of hydrophobic molecules into proteins
    6. Conclusion
    Acknowledgments
    References

    Chapter 8 Transglutaminases in meat and seafood bioprocessing
    Pinar Yerlikaya and Nalan Gokoglu
    1. Transglutaminases in meat bioprocessing
    2. Transglutaminases in seafood bioprocessing
    3. Conclusion
    References

    Chapter 9 Transglutaminase in dairy processing
    Ehab Romeih, Marek Kieliszek and Essam Hebishy
    1. Introduction
    2. MTGase applications in dairy processing
    3. Conclusions and future remarks
    References

    Chapter 10 Transglutaminase in noodles, pastas, and baked products
    Seyed Mohammad Taghi Gharibzahedi and Zeynep Altintas
    1. Introduction
    2. Noodle and TGase
    3. Pasta and TGase
    4. Bread and TGase
    5. Other bakery products and TGase
    6. Health and nutritional properties
    7. Conclusions
    Acknowledgments
    References

    Chapter 11 Transglutaminase in textile, wool, silk, and leather processing
    Ning Zhang, Penghui Yang, Man Zhou, Qiang Wang, Song Liu and Jian Chen
    1. Transglutaminase in wool processing
    2. Transglutaminase in silk processing
    3. Transglutaminase in leather processing
    4. Conclusion
    References

    Chapter 12 Immobilization of transglutaminases and transglutaminase as immobilization agent
    Katja Vasic, Zeljko Knez and Maja Leitgeb
    1. Introduction
    2. Enzymatic properties of TGase
    3. Production and substrate preference of TGase
    4. TGase immobilization
    5. TGase as immobilizing agent in food and
    biotechnology industries
    6. Conclusions
    Acknowledgments
    References

    Chapter 13 Industrial production of transglutaminase
    Keiichi Yokoyama
    1. Background to food innovation with transglutaminase
    2. Feasibility study on protein modification by TGase
    3. Search for a TGase for industrial applications
    4. Developments for MTGase commercialization
    5. MTGase in nature
    6. Recombinant production of MTGase
    7. MTGase variants with improved properties
    8. Food safety and regulation
    9. Concluding remarks
    References
    Further reading

    Index

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    Zhang, Yi; Simpson, Benjamin K.; (ed.)

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