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Recent Advancement in Prodrugs

Recent Advancement in Prodrugs

 
Kiadás sorszáma: 1
Kiadó: CRC Press
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Rövid leírás:

Prodrugs are said to be bioreversible derivatives which on biotransformation change into active pharmacophore. Prodrugs has been extensively studied amongst the drug design scientists for a wide range of applications.  This book will cover the specific examples of prodrugs that overcomes drugs side-effects.

Hosszú leírás:

Recent Advancement in Prodrugs


Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations.



Key features





  • Covers recent advancements in development of prodrugs



  • Presents balanced synthesis and applications of prodrug chemistry



  • Discusses broad spectrum of prodrug categories and outlines industrial applications



  • Reviews prodrugs in cancer nanomedicine, its therapy and treatment



  • Elucidates mathematical models to study the kinetics of prodrugs



This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.

Tartalomjegyzék:

Recent advancements in New drug design and development of prodrugs. Codrugs: Optimum use through prodrugs. Role of Prodrugs in Drug Design. Prodrugs for enhancement of lipophilicity. Lipidic Prodrugs for Drug Delivery:?Opportunities and Challenges. The progress of prodrugs in drug solubility. Prodrugs for CNS drug delivery. Prodrugs for Cancer Treatment. Prodrugs in cancer nanomedicine and therapy. Nitroreductases in prodrug therapies. Prodrug approach using carboxylesterase: Different substrate specificities of human carboxylesterase isozymes. Mathematical models for ADME of prodrugs. Prodrug Approaches for Natural Products. Biotechnology based prodrug approach for cell-specific targeting: its theoretical basis and application.