Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered.

Profiles paraneoplastic diseases by tumor type
Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis
Presents individual syndromes of the CNS, PNS, NMJ, and muscle
Investigates the role of antibody markers
Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities
Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS
Reviews therapeutic strategies and clinical approach to PNS patients

Tartalomjegyzék:

Section I. Introduction and Overview
1. Introduction and overview of immunopathological mechanisms and future directions
2. Changing landscape in the field of paraneoplastic neurology: Personal Perspectives over a 35-year career
3. Pathogenesis and immunopathology of paraneoplastic disorders

Section II. Paraneoplastic neurological syndromes
4. Epidemiology of paraneoplastic neurologic syndromes
5. Clinical approach to diagnosis of paraneoplastic neurological syndromes
6. Overview of treatment strategies in paraneoplastic neurological syndromes
7. Methods to Detect Paraneoplastic Antibodies
8. Paraneoplastic encephalitis
9. Autoimmune and paraneoplastic seizures
10. Paraneoplastic Cerebellar and Brainstem Disorders
11. Paraneoplastic/autoimmune myelopathies
12. Paraneoplastic vision loss
13. Paraneoplastic movement disorders
14. Movement disorders associated with pediatric encephalitis
15. Paraneoplastic neuropathies and peripheral nerve hyperexcitability disorders
16. Paraneoplastic autonomic neuropathies and GI dysmotility
17. Myasthenia Gravis - Pathophysiology, diagnosis and treatment
18. Lambert-Eaton myasthenic syndrome
19. Paraneoplastic myopathies

Section III. Paraneoplastic autoantibodies
20. Intracellular paraneoplastic autoantibodies
21. Antibodies to neural cell surface and synaptic proteins in paraneoplastic neurologic syndromes
22. Optimizing the diagnostic performance of neural antibody testing for paraneoplastic and autoimmune encephalitis in clinical practice

Section IV. Paraneoplastic neurological and autoantibody accompaniments of cancer
23. Paraneoplastic Autoimmune Neurological Disorders associated with Thymoma
24. Paraneoplastic Neurologic Manifestations of Neuroendocrine tumors
25. Paraneoplastic Neurological Syndrome associated with Gynaecological and Breast malignancies
26. Hematological malignancies and hematopoietic stem cell transplantation
27. Paraneoplastic neurological syndrome and autoantibody accompaniments of germ cell tumors

Section V. Neurological complications of cancer immunotherapy
28. Neurological manifestations of autoimmunity with immune checkpoint inhibitors

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