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  • Microbiology of Infectious Disease: Integrating Genomics with Natural History

    Microbiology of Infectious Disease by Primrose, Sandy R.;

    Integrating Genomics with Natural History

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    A termék adatai:

    • Kiadó OUP Oxford
    • Megjelenés dátuma 2022. március 24.

    • ISBN 9780192863850
    • Kötéstípus Puhakötés
    • Terjedelem272 oldal
    • Méret 233x156x12 mm
    • Súly 454 g
    • Nyelv angol
    • 350

    Kategóriák

    Rövid leírás:

    This book reverses the trend towards the biology getting lost in molecular detail by cutting through the information overload and placing the new sequence-derived information in the context of the natural history of the organism in question.

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    Hosszú leírás:

    Prior to the advent of rapid DNA sequencing in the late 90s, students were taught in depth about the physiology and ecology of microorganisms. There was a generally good understanding about the biology of each organism and how it interacted with its environment. Since then, the focus of research has shifted towards an analysis of nucleic acid sequences to determine possible cellular biochemistry or phylogeny. A microbial genome can now be sequenced in a matter of hours, and with the help of a panoply of software programmes the inner workings of the organism can be probed in great detail. However, there is now so much detail that the student or researcher tends to lose any sense of the underlying biology of their study organism. Microbiology has almost become a branch of molecular biology, with the biology getting lost in the molecular detail.

    This novel text reverses that trend by cutting through the molecular information overload and placing the new sequence-derived information in the context of the natural history of the organism in question. Each concise chapter has a fascinating and different story to tell, focussing on one pathogen or group of closely related pathogens and highlighting a particularly interesting and/or unusual feature. The aim is to abstract the relevant molecular and genomic information, and then to show how it provides insights into the biology of the organism as a whole.

    Microbiology of Infectious Disease is aimed at undergraduates, graduates, and researchers in microbiology, microbial ecology, disease ecology, and related areas. It is intended as a supplemental text for students to provide them with a detailed overview of the biology and natural history of the microorganisms they will routinely encounter and the factors that influence their pathogenicity and infectivity.

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    Tartalomjegyzék:

    Preface
    Glossary
    Part I: An Introduction to the Background Science
    The role of nucleic acid analysis in understanding infectious diseases
    Some common factors involved in host-pathogen relations
    The Three Great Pandemics of Plague
    Part II: Bacterial Pathogens
    A Multifaceted Pathogen: Escherichia coli
    Fever and Food Poisoning: The Two Faces of Salmonella
    Understanding Pathogen Populations: Klebsiella pneumoniae
    A Surprising Pathogen: Vibrio cholerae
    The Accidental Pathogen: Legionella pneumophila
    Two Related Pathogens, One Ancient and One New
    Helicobacter pylori and Gastric Ulcers
    A Tale of Two Pathogens: Pseudomonas aeruginosa and Pseudomonas syringae
    The Enigmatic Pathogens: Syphilis, Yaws, Pinta, and Bejel
    Mycobacterial Mysteries: Tuberculosis and Leprosy
    Plasmids and Pathogenicity: The Bacillus cereus Complex
    Tracking the Origins of Clostridium difficile Infections
    Tracking Horizontal Gene Transfer: Staphylococcus aureus
    The Inadvertent Pathogen: Borrelia burgdorferi and Lyme Disease
    Phytoplasmas: Bacteria that Manipulate Plants and Insects
    The Most Influential Bacterium: Wolbachia pipientis
    Part III: Eukaryotic Pathogens
    The Ubiquitous Pathogen: Trichomonas vaginalis
    The Greatest Killer of All Times: The Malarial Parasite
    An Environmental Opportunistic Pathogen: Cryptococcus
    The Most Famous Plant Pathogen: Phytophthora infestans
    Part IV
    A Virus That Promotes Its Own Transfer: Tomato Spotted Wilt Virus
    Morbilliviruses: Measles, Rinderpest and Canine Distemper
    Filovirus Haemorrhagic Fevers: Marburg Virus and Ebola
    The Origins of HIV and the AIDS Pandemic
    The Benefits of a Segmented Genome: Influenza
    Third Time Unlucky: SARS, MERS, and Covid-19
    Part V: Some Unifying Themes
    Zoonotic Diseases
    Some Common Pathogenicity Themes

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    Microbiology of Infectious Disease: Integrating Genomics with Natural History

    Microbiology of Infectious Disease: Integrating Genomics with Natural History

    Primrose, Sandy R.;

    20 998 Ft

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