Rövid leírás:

This book presents an intensive review of the anatomy, physiology and pharmacology of the systems that mediate nociceptive processing. The authors also cover important clinical concepts with specific emphasis on mechanisms of action.

Hosszú leírás:

Pain is a serious health problem. This book presents an intensive review of the anatomy, physiology, and pharmacology of the systems that mediate nociceptive processing. The authors cover areas that include anatomy, central and peripheral nerve processing, tissue and nerve injury states, as well as preclinical models of pain.

Mechanisms of Pain also covers important clinical concepts, with specific emphasis on mechanisms of action. Written by UCSD faculty awarded by the American Academy of Pain Medicine top pain fellowship teaching program, this book covers important areas of science required to understand pain medicine. They discuss post?tissue and nerve injury pain states of primary afferents and the spinal cord. The authors also cover mechanisms of action of clinically relevant analgesics (opiates and non-opiates). The authors also cover psychological aspects of pain and the pathophysiology of migraines, as well as the genetics of pain.

This comprehensive book is to guide undergraduate, graduate, and clinicians in the field of pain medicine on important concepts related to the science of pain.

Tartalomjegyzék:

Chapter 1- Introductory and Key Concepts in the Basis of Pain

Chapter 2- Organization of the Nervous System: Gross Anatomy

Chapter 3- Neurophysiology of Pain ? Peripheral

Chapter 4- DRG/Peripheral Nerve: Multicellular Modality and Coding

Chapter 5- Peripheral Nerve and Dorsal Root Ganglion (DRG) Pharmacology: Mechanisms, Therapeutic Targets, and Clinical Applications

Chapter 6- Dorsal Horn Organization and Processing

Chapter 7- The Psychophysiology of Pain

Chapter 8-  Post Tissue Injury Pain State ? Primary Afferent

Chapter 9- Post Tissue Injury Pain State ? Spinal Cord

Chapter 10- Post Nerve Injury Pain States (Primary Afferent)

Chapter 11- Spinal Cord

Chapter 12- Visceral Pain System/ Neuro-Immune Interaction 

Chapter 13- Preclinical Models of Pain

Chapter 14- Human Experimental Pain Models: Clinical Applications and Molecular Mechanisms in Drug Development

Chapter 15- Psychological Aspects of Pain: A Focus on Depression

Chapter 16- Neuromodulation 

Chapter 17- Mechanisms of Action of Clinically Relevant Analgesics (Opioids)

Chapter 18- Mechanisms of Action of Clinically Relevant Analgesics (Non-Opiates)

Chapter 19- ?Pathophysiology of Migraine?

Chapter 20- Genetics of Pain

Chapter 21- Chronic Low Back Pain: Etiology and Treatment