| ISBN13: | 9781032827940 |
| ISBN10: | 1032827947 |
| Kötéstípus: | Keménykötés |
| Terjedelem: | 686 oldal |
| Méret: | 280x210 mm |
| Súly: | 1430 g |
| Nyelv: | angol |
| Illusztrációk: | 29 Illustrations, black & white; 172 Illustrations, color; 13 Halftones, black & white; 56 Halftones, color; 16 Line drawings, black & white; 116 Line drawings, color; 198 Tables, black & white; 28 Tables, color |
| 695 |
Az orvostudomány általános kérdései
Immunológia, allergológia
Klinikai orvostudomány és belgyógyászat általában
Reumatológia
Az orvostudomány általános kérdései (karitatív célú kampány)
Immunológia, allergológia (karitatív célú kampány)
Klinikai orvostudomány és belgyógyászat általában (karitatív célú kampány)
Reumatológia (karitatív célú kampány)
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
GBP 180.00
Kattintson ide a feliratkozáshoz
A Prosperónál jelenleg nincsen raktáron.
This book summarizes the progress made across the international medical and scientific research communities towards the goal of converting a chronic autoimmune disease into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies to generate sustained immune tolerance.
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn?s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.
Key Features
- Outlines therapies and techniques for HSCT for autoimmune diseases
- Discusses the advantages of HSCT over conventional therapies
- Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
"Over the past 25 years, the utilization of hematopoietic stem cell transplantation (HSCT) specifically for the treatment of autoimmune diseases has gradually evolved from an initial state of ?salvage therapy? for severely affected patients towards a ?standard procedure? for selected patients in the major indications multiple sclerosis (MS) and systemic sclerosis (SSc). The recently published book entitled ?Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases? now summarizes all recent developments and achievements in the area and provides the evidence and state-of-the-art of HSCT and emerging cellular therapies. The selected topics comprehensively highlight all relevant aspects of the procedures. The book was developed under the direction of Richard Burt from the Northwestern University, Chicago, one of pioneers and most eminent leaders in the field, in collaboration with the co-editors Dominique Farge, Milton A Ruiz, Riccardo Saccardi and John A Snowden. The book will attract a broad readership, particularly clinical scientists, clinicians and fellows dedicated to HSCT, both from a hematologic or autoimmune disease perspective.
Overall, this book summarizes all relevant milestones in the field, extensively covering HSCT and cellular therapies in ADs, a field characterized by ongoing progress. It reflects on the dramatic developments and achievements of cellular therapies in recent years, along the dynamics of modern biologic and targeted therapies for ADs. The book is a valuable reading, serving as an ideal manual of good practices for hematologists, disease specialists, as well as researchers and young physicians. Finally, the book acknowledges the contributions and efforts of individual experts and personalities, first and foremost Richard Burt, all the co-editors and the authors of the book, to whom we bow for this work."
- Tobias Alexander and Raffaella Greco and on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP)
- Tobias Alexander, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany.
- Raffaella Greco, Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
"This is a comprehensive collection of current knowledge on hematopoietic stem cell transplantation therapy for immune diseases. With 140 international experts in the field, this book serves as a valuable resource for those who
practice and research in the field of transplantation and those who use such knowledge to care for their patients."
- Massoud Mahmoudi, DO, PhD, University of California San Francisco
Table of Contents
Section 1- Biology of Immune Cells
Ch 1 B cells in aging, age-associated diseases and stem cell transplantation
Ch 2 T cell biology: changes with disease, aging, and hematopoietic stem cell transplantation
Ch 3 Plasma cells in autoimmunity
Ch 4 CAR T cells for Autoimmunity
Ch 5 Regulatory T cells for the treatment of autoimmune diseases
Ch 6 Mesenchymal Stromal Cells Derived Extracellular Vesicles
Section 2 - Biology of Stem Cells
Ch 7 Induced Pluripotent Stem Cells: the story of genetic reprogramming
Ch 8 Mesenchymal stromal cell biology and clinical application
Ch 9 Neural Stem Cell Biology
Ch 10 Hematopoietic stem cells: Hierarchical versus Continuum
Ch 11 Biology of Umbilical Cord Blood Cells
Section 3 ? Regulatory requirements
Ch 12 Quality, Accreditation, and Regulation in HSCT and Cellular Therapy for Autoimmune Diseases
Ch 13 EUROPEAN PERSPECTIVE ON CELLULAR THERAPY: GOOD TISSUE PRACTICE (GTP) VERSUS GOOD MANUFACTURING PRACTICE (GMP).
Ch 14 GMP Facility Requirements in the United States of America
Section 4 ? Mesenchymal Stem Cells for Immune Diseases
Ch 15 Mesenchymal stromal cell therapy for acute graft versus host disease ? from bench to clinical approval
Ch 16 Adipose-Derived Stem Cells for Systemic Sclerosis Digital Ulcers
Ch 17 Musculoskeletal stromal/progenitor cells-based cell therapy for Rheumatoid Arthritis (RA)
Ch 18 Mesenchymal Stromal cells for Systemic Sclerosis
Ch 19 Mesenchymal stem cells (MSC) for systemic lupus erythematosus (SLE)
Ch 20 Mesenchymal stem/stromal cells for multiple sclerosis and other neurological diseases
Ch 21 Mesenchymal stromal cells for perianal fistulizing crohn?s disease
Ch 22 Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder
Section 5 ? General concepts: HSCT for Autoimmune Diseases
Ch 23 Animal models of bone marrow transplantation for autoimmune diseases
Ch 24 Autologous HSCT conditioning regimens for autoimmune diseases
Ch 25 Immune reconstitution after hematopoietic stem cell transplantation in autoimmune disease
Ch 26 Microbiota and immune response
Ch 27 Infectious complications in patients undergoing HSCT for autoimmune diseases.
Ch 28 Early Toxicity and Supportive Care of HSCT for Autoimmune Diseases
Ch 29 Late toxicity and supportive care of patients undergoing haematopoietic cell transplantation for autoimmune diseases
Ch 30 Transfusion Medicine
Ch 31 International Registries Sites / Indications / Activity for HSCT in Autoimmune Diseases: the European Society for Blood and Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR)
Ch 32 Hematopoietic stem cell mobilization, collection, apheresis, and harvest procedures
Section 6 ? Allogeneic HSCT for Autoimmune disease
Ch 33 Hematopoietic Stem Cell Donor Registries: Search Strategies and HLA Methodologies
Ch 34 Allogeneic HSCT and Graft-versus-Host Disease (GvHD): general principles with reference to autoimmune diseases
Ch 35 Haematopoietic cell transplantation in monogenic autoimmune diseases
Ch 36 Advances In The Pathogenesis And Treatment Of Immune Mediated Aplastic Anemia
Section 7- HSCT for autoimmune disease Multiple Sclerosis
Ch 37 Magnetic Resonance Imaging in Multiple Sclerosis
Ch 38 Multiple Sclerosis
Ch 39 Disease-modifying therapies and supportive care of multiple sclerosis
Ch 40 Autologous hematopoietic stem cell transplantation for Secondary Progressive Multiple Sclerosis
Ch 41 Autologous hematopoietic stem cell transplantation for Relapsing Remitting Multiple Sclerosis
Ch 42 Immune mechanisms of autologous hematopoietic stem cell transplantation for multiple sclerosis
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Ch 43 Basics and interpretation of electrodiagnostic testing
Ch 44 Diagnosis and Differentiation of CIDP from other peripheral polyneuropathies
Ch 45 Hematopoietic stem cell transplantation for chronic inflammatory demyelinating polyradiculoneuropathy
Neuromyelitis Optica
Ch 46 Autologous and Allogeneic HSCT for AQP4-IgG positive Neuromyelitis Optica Spectrum Disorders
Systemic Sclerosis
Ch 47 Systemic Sclerosis
Ch 48 The Systemic Sclerosis Heart
Ch 49 Scleroderma Renal Crisis with special considerations for Autologous Hematopoietic Stem Cell Transplant
Ch 50 Systemic Sclerosis and the Lung
Ch 51 AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN SYSTEMIC SCLEROSIS
Crohn Disease
Ch 52 Crohn?s Disease: Incidence, Diagnosis, Standard Treatment, Prognosis, Outcome Measures
Ch 53 Hematopoietic Stem cell transplantation an alternative to treat Crohn?s disease
Type I Diabetes Mellitus
Ch 54 Hematopoietic Stem Cell Transplantation for Type I Diabetes Mellitus
Systemic Lupus Erythematosus
Ch 55 Hematopoietic stem cell transplantation for systemic lupus erythematosus (SLE)
Celiac Disease
Ch 56 Hematopoietic Stem Cell Transplantation for Refractory Celiac Disease type II
Section 8 ? Developing indications for HSCT
Ch 57 Haematopoietic stem cell transplantation for Juvenile Idiopathic Arthritis
Ch 58 Haematopoietic Stem Cell Transplantation for Rheumatoid Arthritis
Ch 59 Hematopoietic Stem Cell Transplantation for Behçet's Syndrome
Ch 60 Hematopoietic Stem Cell Transplantation and Myasthenia Gravis
Ch 61 Autologous Haematopoietic Stem Cell Transplantation in Stiff Person Spectrum Disorder
Ch 62 Hematopoietic Stem Cell Transplant-Based Treatment for Psychiatric Disorders
Ch 63 Hematopoietic Stem Cell Transplantation for Psoriasis and Pemphigus Vulgaris
Section 9 ? Ethics and economics
Ch 64 Health Economics of Multiple Sclerosis
Ch 65 Ethics of Stem Cells and Stem Cell Transplantation for Autoimmune diseases
Ch 66 Is Healthcare a Human Right?
Ch 67 Appendices
