Fundamentals of Next?generation DNA Sequencing
Kiadó: Wiley VCH
Megjelenés dátuma: 2023. január 12.
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A termék adatai:
| ISBN13: | 9783527336401 |
| ISBN10: | 35273364011 |
| Kötéstípus: | Puhakötés |
| Terjedelem: | 350 oldal |
| Nyelv: | angol |
| 578 |
Témakör:
Rövid leírás:
This book is the first textbook on Next Generation Sequencing (NGS) platforms suitable for undergraduate and postgraduate students as well as for courses in industry.
Hosszú leírás:
This book is the first textbook on Next Generation Sequencing (NGS) platforms suitable for undergraduate and postgraduate students as well as for courses in industry.
Tartalomjegyzék:
1. Introduction: Human genome project
1.1 Sanger sequencing
1.2 Sequencing of the first human genome
1.3 Origins of pharmacogenomics: Technology limitations
2. Next?generation DNA sequencing techniques
2.1 Why do we call it next generation?
2.2 Illumina sequencing
2.2.1 Reversible terminator technology
2.2.2 HiSeq
2.2.3 MiSeq
2.3 Roche sequencing
2.3.1 Pyrosequencing chemistry
2.3.2 Genome Sequencer
2.3.3 Junior GS
3. NGS data analysis
3.1 Specific features of NGS data
3.2 What needs to be done to decipher short sequence reads?
3.3 Mapping to the reference genome
3.4 Assembly of the genome or transcriptome
3.5 De novo sequence assembly
3.6 Pathway analysis
4. NGS applications in research
4.1 Reference genomes
4.2 Transcriptome sequencing: RNA?Seq, RIP?Seq, directional RNA?Seq
4.3 ChIP?Seq: genome?wide DNA? and RNA?protein interactions
4.4 Whole genome re?sequencing
4.5 Exome sequencing
4.6 Epigenomics
4.7 Metagenomics
4.8 De novo sequencing of microbial genomes
4.9 Plant genomics
5. Emerging NGS areas
5.1 Consumer genomics
5.1.1 Genotyping for determination of disease susceptibility
5.1.2 Ancestry testing
5.1.3 Direct?to?consumer genomics: Ethical and social issues
5.2 Clinical sequencing
5.2.1 Profiling of somatic mutations in cancer
5.2.2 Down Syndrome
5.2.3 Rare genetic diseases
5.2.4 Clinical trials for patients stratifications
5.2.5 Pharmacogenomics
5.2.6 Drug response studies
6. Future directions
6.1 Nanopore sequencing
6.2 Evolutionary genetics on the genome?wide scale
1.1 Sanger sequencing
1.2 Sequencing of the first human genome
1.3 Origins of pharmacogenomics: Technology limitations
2. Next?generation DNA sequencing techniques
2.1 Why do we call it next generation?
2.2 Illumina sequencing
2.2.1 Reversible terminator technology
2.2.2 HiSeq
2.2.3 MiSeq
2.3 Roche sequencing
2.3.1 Pyrosequencing chemistry
2.3.2 Genome Sequencer
2.3.3 Junior GS
3. NGS data analysis
3.1 Specific features of NGS data
3.2 What needs to be done to decipher short sequence reads?
3.3 Mapping to the reference genome
3.4 Assembly of the genome or transcriptome
3.5 De novo sequence assembly
3.6 Pathway analysis
4. NGS applications in research
4.1 Reference genomes
4.2 Transcriptome sequencing: RNA?Seq, RIP?Seq, directional RNA?Seq
4.3 ChIP?Seq: genome?wide DNA? and RNA?protein interactions
4.4 Whole genome re?sequencing
4.5 Exome sequencing
4.6 Epigenomics
4.7 Metagenomics
4.8 De novo sequencing of microbial genomes
4.9 Plant genomics
5. Emerging NGS areas
5.1 Consumer genomics
5.1.1 Genotyping for determination of disease susceptibility
5.1.2 Ancestry testing
5.1.3 Direct?to?consumer genomics: Ethical and social issues
5.2 Clinical sequencing
5.2.1 Profiling of somatic mutations in cancer
5.2.2 Down Syndrome
5.2.3 Rare genetic diseases
5.2.4 Clinical trials for patients stratifications
5.2.5 Pharmacogenomics
5.2.6 Drug response studies
6. Future directions
6.1 Nanopore sequencing
6.2 Evolutionary genetics on the genome?wide scale