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Functional Groups in Biochemistry: Tailored Chemistry in Biological Contexts includes detailed mechanisms of reactions, focusing on functional groups and their chemical/biochemical properties that determine the biological functions of macromolecules, a connection often overlooked or under-emphasized in standard textbooks. The book provides a deeper understanding of the governing principles of biochemical reactions, as well as how key chemical and biochemical reactions are thought to occur at the atomic/molecular level. With an emphasis on common themes that govern biochemical reactivity, this book fills the gap between organic/bioorganic chemistry and biochemistry texts.

• Fills the gap between organic/bioorganic chemistry and biochemistry texts
• Illustrates how key functional groups in biochemistry dictate behaviors in proteins, nucleic acids, or polysaccharides
• Focuses on functional groups and their chemical/biochemical properties that determine the biological functions of macromolecules

Tartalomjegyzék:

Introduction and General Principles

1
(a) Hydroxyl R-OH
(b) Thiol R-SH

2
(a) Ether R₁-O-R₂
(b) Thioether R₁-S-R₂

3
(a) Disulfide R₁-S-S-R₂
(b) Peroxide R-O-O-H
R₁-O-O-R₂

4
(a) Carboxyl R-COOH
(b) Carboxyester R₁-C(=O)-OR₂
(c) Imidate R₁-C(=NH)-OR₂
(d) Thioester R₁-C(=O)-SR₂
(e) Phosphoester R₁-O-PO₃H₂
R₁-O-P(O₂H)-R₂
R₁-O-P(O)(OR₂)(OR₃)
(f) Sulfoester R₁-O-SO₂OH
R₁-O-SO₂-O-R₂

5
(a) Aldehyde R-CHO
(b) Carbonyl R₁-C(=O)-R₂
(c) Imine R-CH(=NH)
R₁-C(=NH)-R₂

6
(a) Ketoacid R-C(=O)-COOH
(b) Ketoacid R-C(=O)-CH₂-COOH
R1-C(=O)-CHR₂-COOH
R1-C(=O)-CR₂R₃-COOH

7
(a) Amine R₁R₂NH
R₁R₂R₃N
R₁R₂R₃R₄N⁺
(b) Amide R-C(=O)-NH₂
R1-C(=O)-NHR₂
R1-C(=O)-NR₁R₂
(c) Amidine R1-C(=NH)-NH₂

8
(a) Phosphoanhydride R-O-P(O)(OH)-O-P(O)(OH)₂
R₁-O-P(O)(OH)-O-P(O)(OH)-OR₂
(b) Mixed Anhydride R-C(=O)-O-P(=O)O₂H₂
R₁-C(=O)-O-P(=O)(OR₂)(OH)

9
(a) Hemiacetal R₁-O-CHR₂-OH
(b) Acetal R₁-O-CHR₂-OR₃
(c) Hemiketal R₁-O-CR₂R₃-OH
(d) Ketal R₁-O-CR₂R₃-OR₄

Concluding Remarks
References