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**Selected for 2025 Doody’s Core Titles? in Biochemistry**

Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field.

In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease.

Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care - including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.

• A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D
• Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientificand clinical aspects of vitamin D, as opposed to searching through thousands of journal articles
• Chapters written by the most prominent and well-published names in the field

*4 stars* "...an encyclopedically extensive comprehensive reference on our current state of knowledge and contemporary research into this intriguingly complex micronutrient.... [F]eatures expanded content and increased emphasis on the role vitamin D plays in human health, including insights revealed by the Covid pandemic. The book represents a rich and extensive reference for anyone interested in the biology, metabolism, mechanism of action, and pathology of vitamin D,... the product of over 200 contributors.... A robust collection of informative and well-constructed figures and tables, including many that present primary research data that add depth to the presentation, complements the text. [I]mpressively comprehensive in scope, well organized, and clearly written.... [A] truly encyclopedic resource regarding all things vitamin D. As such, ...the essential reference on this important micronutrient." --?Doody’s Review Service, 2024, Peter J. Kennelly, PhD (Virginia Tech)

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Tartalomjegyzék:

1. Book introduction: Major trends in vitamin D research;
2. Evolution of human skin pigmentation and vitamin D;
3. Photobiology of vitamin D;
4. The activating enzymes of vitamin D metabolism (25- and 1?-hydroxylases);
5. CYP24A1: structure, function, and physiological role;
6. Alternative pathways for vitamin D metabolism;
7. Vitamin Debinding protein;
8. Regulation of renal vitamin D metabolism;
9. Regulation of extra-renal synthesis of 1,25(OH)2D;
10. Structural basis for ligand activity in vitamin D receptor;
11. Genome-wide perspectives on vitamin D receptor actions;
12. Vitamin D, chromatin, and epigenetics;
13. The diverse genomic mechanisms of action of the vitamin D receptor;
14. Vitamin D and microRNAs;
15. Pathway based-analysis of transcriptomic data from vitamin D studies
16. Vitamin D and the kidney;
17. Vitamin D and the calcium-sensing receptor;
18. Regulation of intestinal calcium and phosphate absorption by vitamin D;
19. Vitamin D and FGF23;
20. Osteoclastogenesis and vitamin D;
21. Vitamin D activity in osteoblasts and osteocytes;
22. Cartilage;
23. Vitamin D and bone: an integrated approach;
24. Vitamin D in dentoalveolar and oral health;
25. Role of vitamin D in skin and hair biology;
26. Vitamin D and the cardiovascular system;
27. Vitamin D, brain development and function;
28. Vitamin D, VDR, and adipose tissue: focus on cellular mechanisms;
29. Vitamin D and skeletal muscle;
30. Understanding vitamin D from mouse knockout models;
31. Pharmacology and pharmacokinetics of vitamin D;
32. Vitamin D as a modifier of genomic function and phenotypic expression during pregnancy;
33. The role of vitamin D physiology in regulating calcium and bone metabolism in mother and child: pregnancy, lactation, postweaning, fetus, and neonate;
34. Vitamin D and the placenta;
35. Consequences of perinatal vitamin D deficiency on later bone health;
36. Adolescence and acquisition of peak bone mass;
37. The role of vitamin D in orthopedic surgery;
38. Vitamin D and muscle performance in athletes and older adults;
39. Role in reproductive biology and dysfunction in women;
40. Vitamin D, reproductive endocrinology, and male reproductive organ function in health and disease;
41. Vitamin D and the renineangiotensin system;
42. Vitamin D: presence and function in the eye;
43. Adult vitamin D deficiency and adverse brain outcomes
44. Vitamin D and the lung;
45. Design and synthesis of vitamin D analogs;
46. Structure function relationships of VDR ligands;
47. Modulating vitamin D receptore coregulator binding with small molecules;
48. Mass spectrometry assays of vitamin D metabolites;
49. Measurement and quality assessment of total and free 25-hydroxyvitamin D;
50. Vitamin D tissue distribution by mass spectrometry imaging;
Index for Volume 1

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