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Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.

Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.

• Provides detailed overviews of the biology, including phylogenesis, biogenesis and distribution of expression, of cholecystokinin peptides and receptors
• Explores the physiology of CCK, its metabolic functions, and role in a range of medical conditions, including obesity, type 2 diabetes, tumors, nociception, and cerebral disease
• Considers the latest developments in CCK-based therapeutic approaches and future directions for CCK research

Tartalomjegyzék:

Part I - History
1. Milestones in the history of cholecystokinin
Jens F. Rehfeld, Christine Feinle-Bisset

Part II - Biology of cholecystokinin
2. Evolutionarily conserved roles of cholecystokinin signaling
Dick Nässel, Shunfan Wu

3. The biogenesis and cell-specific expression of cholecystokinin peptides
Jens F. Rehfeld, Christine Feinle-Bisset

4. Cholecystokinin in intestinal and extraintestinal endocrine cells
Marta Santoz Hernandez, Frank Reimann, Fiona M. Gribble

5. Cholecystokinin in the central and peripheral nervous system
Tomas Hökfelt, Swapnali Barde, Wen Zhong, Jufang He

6. Cholecystokinin 1 and cholecystokinin 2 receptors
Laurence J Miller

7. The relationship between cholecystokinin and gastrin
Jens F. Rehfeld

Part III - Physiology of cholecystokinin
8. Intestinal cholecystokinin secretion
Rashmi Chandra, Rodger A. Liddle

9. Cholecystokinin and the gut-brain axis
Kirsteen Browning, Amanda Page

1. Cholecystokinin and the gallbladder

Adrian A. M. Masclee, Gwen M. C. Masclee

11. Cholecystokinin and the exocrine pancreas
John A. Williams

12. Islet effects of cholecystokinin and exploitation in diabetes
Neil Tanday, Nigel Irwin, Peter Flatt

13. Cholecystokinin and gastrointestinal motor function
Javad Anjom Shoae, Michael Horowitz, Christine Feinle-Bisset

14. Effect of cholecystokinin on food intake and appetite
Frank A. Duca

15. Cholecystokinin, nutrient preference and taste aversion
Jo E. Lewis, Fiona M. Gribble, Frank Reimann

16. Cholecystokinin in peripheral and central cardiovascular control
Tony J. M. Verberne, Bashair M. Mussa

17. Cholecystokinin in cardiac myocytes
Jens P. Goetze, Jens F. Rehfeld

Part IV - Methods used for cholecystokinin research
18. Measurement of cholecystokinin in biological fluids
Jens F. Rehfeld, Jens P. Goetze

19. Cholecystokinin knockout mice: peripheral and central phenotypes
Chunmin C. Lo, Dennis D. Black, Patrick Tso

Part V - cholecystokinin in disease
20. Cholecystokinin in obesity and other disorders of eating
Kimberly R. Smith, Tim H. Moran

21. Cholecystokinin in tumors
Jens F. Rehfeld

22. Cholecystokinin and panic disorder
Jacques Bradwejn, Diana Koszycki

23. Cholecystokinin and the immune system
John J. Worthington

24. Cholecystokinin in nociception and pain
Nesia A. Zurek, Sascha R. A. Alles

Part VI - cholecystokinin -based novel therapeutic approaches
25. Potential therapeutics targeting cholecystokinin 1 receptors
Laurence J. Miller

Part VII - Conclusion
26. Reflections on cholecystokinin research: past, present and future
Jens F. Rehfeld, Christine Feinle-Bisset